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On the accumulation of 35S-chlorpromazine in the adrenal gland

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Summary

The distribution of 35S-labelled chlorpromazine (35S-CPZ) in the adrenal glands was studied in vivo in mice and cats and in vitro in perfused bovine adrenal glands. In addition the effect of a quaternary phenothiazine derivative, N-hydroxyethylpromethazine (NHP), on the distribution of 35S-CPZ both in vivo and in vitro and that of insulin, lidocain and plasma in vitro were examined.

In vivo the degree of radioactivity was at first high in the cortex of adrenal glands. Later the distribution became more diffuse, and in cats still more radioactivity was concentrated in the medulla. There was no clear differences between the animals treated with 35S-CPZ alone and those pretreated with NHP.

In vitro the radioactivity was higher in the medulla. NHP made the distribution more diffuse and delayed the outflow of 35S-CPZ from the adrenals. Also, insulin made the distribution more diffuse, and strong activity was recorded in the cortex. Plasma in place of salt solution as perfusion fluid caused more equal disposition of activity between the medulla and the cortex and lidocain added to the plasma made the distribution still more equal.

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Authors and Affiliations

  1. Department of Pharmacology, University of Helsinki, Helsinki, Finland

    H. I. Vapaatalo, J. E. Idänpään-Heikkilä & P. J. Neuvonen

Authors
  1. H. I. Vapaatalo
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  2. J. E. Idänpään-Heikkilä
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  3. P. J. Neuvonen
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Additional information

This work was supported by Jalmari and Rauha Ahokas foundation and the Finnish Medical Research Council.

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Vapaatalo, H.I., Idänpään-Heikkilä, J.E. & Neuvonen, P.J. On the accumulation of 35S-chlorpromazine in the adrenal gland. Psychopharmacologia 13, 14–21 (1968). https://doi.org/10.1007/BF00401614

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  • DOI: https://doi.org/10.1007/BF00401614

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