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Effects of α-methyl-Dopa on conditioned behaviour in the cat

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Summary

After α-methyl-DOPA (α-MD) administration to cats a significant decrease of a conditioned avoidance response (CAR) was observed 8 hours later. In reserpine-pretreated cats α-MD caused a pronounced reduction of CAR which was not reversed by (+)-amphetamine. A subsequent administration of l-DOPA resulted in a dose-dependent CAR reversal. Different possibilities of the central action exerted by α-MD are discussed.

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Authors and Affiliations

  1. Department of Pharmacology, University of Göteborg, Sweden

    L. C. F. Hanson & M. Henning

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  1. L. C. F. Hanson
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  2. M. Henning
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Hanson, L.C.F., Henning, M. Effects of α-methyl-Dopa on conditioned behaviour in the cat. Psychopharmacologia 11, 1–7 (1967). https://doi.org/10.1007/BF00401503

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  • DOI: https://doi.org/10.1007/BF00401503

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