Abstract
Rats of the Maudsley strains were trained in the Hebb-William's maze under three levels of food deprivation, i.e. 22, 25, and 7 h (drives) for 10 consecutive days. Immediately after each daily trial the experimental animals of all three drives were injected with a 1.0 mg/kg dose of picrotoxin, and the animals of the control groups were administered distilled water. Picrotoxin increased the efficiency of learning at all levels of drive, and higher drive level resulted in greater performance. The Reactive strain performed better in the maze learning than the Non-Reactive.
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References
Anokhin, P. K.: The multiple ascending influences of the subcortical centers on the cerebral cortex. In: Brazier, M. A. B. (Ed.): Brain and Behavior, vol. 1, pp. 139–170. Amer. Inst. Biol. Sci., Washington, D.C. 1961.
Bindra, D., Mendelson, J.: Training, drive level, and drug effects: A temporal analysis of their combined influence of behavior. J. comp. physiol. Psychol. 56, 183–189(1963).
Broadhurst, P. L.: Emotionality and the Yerkes-Dodson Law. J. exp. Psychol. 54, 345–352 (1957).
Eisman, E.: An investigation of the parameters defining drive. J. exp. Psychol. 52, 85–89 (1956).
Garg, M., Holland, H. C.: Consolidation and maze learning: A comparison of several post-trial treatments. Life Sci. 6, 1987–1997 (1967).
— —: Consolidation and maze learning: a further study of post-trial injections of a stimulant drug (nicotine). Int. J. Neuropharmacol. 7, 55–59 (1968).
— —: Consolidation and maze learning: the effects of post-trial injections of a stimulant drug (picrotoxin). Psychopharmacologia (Berl.) 12, 96–103 (1968).
Hull, C. L.: Principles of behavior. New York: Appleton Century Crofts 1943.
Mendelson, J., Bindra, D. B.: Combination of drive and drug effects. J. exp. Psychol. 63, 505, 509 (1962).
Payne, R. B.: An extension of hullian theory to response decrements resulting from drugs. J. exp. Psychol. 55, 342–346 (1958).
Petrinovitch, L., Eisenstein, E.: Drug facilitation of learning problems of strain and species, reported at A. A. A. S. Dec. Meeting, 1965, Berkeley, Calif.
Robinovitch, M. S., Rasvold, M. E.: A closed-field intelligence test for rats. Canad. J. Psychol. 5, 122–128 (1951).
Yaktin, U. S., Eysenck, H. J.: Generalised Drive: An experimental study of the interaction of the drives. In: Eysenck, H. J. (Ed.): Experiments in Motivation, pp. 338–374. Oxford: Pergamon Press 1964.
Pearson, E. S., Hartley, H. O.: Biometrical table for statisticians, Vol. I. London: Cambridge Univ. 1958.
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This work was carried out at the Institute of Psychiatry, London S.E. 5.
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Garg, M. Combined effect of drug and drive on the consolidation process. Psychopharmacologia 18, 172–179 (1970). https://doi.org/10.1007/BF00401499
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DOI: https://doi.org/10.1007/BF00401499