Psychopharmacologia

, Volume 22, Issue 1, pp 23–30 | Cite as

The effect of two tetrahydrocannabinols, (Δ9-THC and Δ8-THC) on conditioned avoidance learning in rats and its transfer to normal state conditions

  • Bengt G. Henriksson
  • Torbjörn Järbe
Original Investigations Animal Studies

Abstract

Rats trained in conditioned avoidance responding (CAR) after injections of either 7.5 mg/kg Δ9-THC (tetrahydrocannabinol) or 15 mg/kg Δ8-THC, showed no transfer when tested in the non-drugged state. Furthermore, these doses of the isomeric tetrahydrocannabinols exerted a disruptive effect on previously established CAR in rats, trained under normal conditions.

Only the Δ9-THC-group showed an impairment of acquisition which was statistically significant compared to the control group.

Key-Words

Acquisition CAR Tetrahydrocannabinols Transfer Rat 

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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Bengt G. Henriksson
    • 1
    • 2
  • Torbjörn Järbe
    • 1
    • 2
  1. 1.Department of PsychologyUniversity of UppsalaUppsalaSweden
  2. 2.Neurophysiological Laboratory, Psychiatric Research CenterUlleråker HospitalUppsalaSweden

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