The effect of two tetrahydrocannabinols, (Δ9-THC and Δ8-THC) on conditioned avoidance learning in rats and its transfer to normal state conditions
- 32 Downloads
Rats trained in conditioned avoidance responding (CAR) after injections of either 7.5 mg/kg Δ9-THC (tetrahydrocannabinol) or 15 mg/kg Δ8-THC, showed no transfer when tested in the non-drugged state. Furthermore, these doses of the isomeric tetrahydrocannabinols exerted a disruptive effect on previously established CAR in rats, trained under normal conditions.
Only the Δ9-THC-group showed an impairment of acquisition which was statistically significant compared to the control group.
Key-WordsAcquisition CAR Tetrahydrocannabinols Transfer Rat
Unable to display preview. Download preview PDF.
- Abel, E. L.: Marijuana and memory. Nature (Lond.) 227, 1151–1152 (1970).Google Scholar
- —, Kramer, C.: Effects of Cannabis sativa (marihuana) on maze performance of the rat. Psychopharmacologia (Berl.) 7, 175–181 (1965).Google Scholar
- Garattini, S.: Effects of a cannabis extract on gross behaviour. In: Ciba Foundation Study Group No. 21: Hashish: its chemistry and pharmacology. London: Churchill 1965.Google Scholar
- Gill, E. W., Paton, W. D. M., Pertwee, R. G.: Preliminary experiments on the chemistry and pharmacology of Cannabis. Nature (Lond.) 228, 134–136 (1970).Google Scholar
- Grunfeld, Y., Edery, H.: Psychopharmacological activity of the active constituents of hashish and some related cannabinoids. Psychopharmacologia (Berl.) 14, 200–210 (1969).Google Scholar
- Loewe, S.: Principle of “bioassay by approximation” and its application to the assay of marihuana (dog) and laxatives (monkey). J. Pharmacol. exp. Ther. 66, 23–24 (1939).Google Scholar
- Masur, J., Märtz, R. M. W., Carlini, E. A.: Effects of acute and chronic administration of cannabis sativa and (−)-Δ 9-trans-tetrahydrocannabinol on the behavior of rats in an open-field arena. Psychopharmacologia (Berl.) 19, 388–397 (1971).Google Scholar
- McMillan, D. E., Harris, L. S., Frankenheim, J. M., Kennedy, I. S.: 1-PuitΔ 9-transtetrahydrocannabinol in pigeons: Tolerance to the behavioral effects. Science 169, 501–503 (1970).Google Scholar
- —: State-dependant learning produced by depressant and atropine-like drugs. Psychopharmacologia (Berl.) 10, 6–31 (1966).Google Scholar
- —: Dissociated learning in drug states (state dependant learning), pp. 918–930. In: D. H. Efron (Ed.): Psychopharmacology—A review of progress, 1957–1967. U.S. Government Printing Office, Washington 1968.Google Scholar
- Siegel, S.: Nonparametric statistics for the behavioral sciences, pp. 116–127. New York-Toronto-London: McGraw-Hill 1956.Google Scholar
- Silva, M. T. A., Carlini, E. A., Claussen, V., Korte, F.: Lack of cross-tolerance in rats among(−)-Δ 9-transtetrahydrocannabinol (Δ 9-THC), Cannabis extract, mescaline and lysergic acid diethylamide (LSD-25). Psychopharmacologia (Berl.) 13, 332–340 (1968).Google Scholar
- Valle, J. R.: Pharmacological approaches to the study of the cannabis problem. Int. J. Addict. 4, 623–647 (1969).Google Scholar