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A possible relationship between catecholamines and acute toxicity of desipramine

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Summary

Acute toxicity of desipramine in mice was shown to be influenced by other drugs. Pretreatment with reserpine but not with chlorpromazine, disulfiram, or p-chlorophenylalanine protected mice against desipramine toxicity. Reserpine protection was reversed by dopa or dopa and disulfiram but not by methyldopa or 5-hydroxytryptophan. These results suggested a relationship between catecholamines and desipramine toxicity.

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Authors and Affiliations

  1. Department of Pharmacology, University of Kansas, Lawrence, Kansas

    Harbans Lal & Roger M. Brown

  2. Department of Pharmacology, University of Rhode Island, 02881, Kingston, Rhode Island, USA

    Harbans Lal

  3. Department of Pharmacology, University of Chicago, Chicago, Illinois

    Roger M. Brown

Authors
  1. Harbans Lal
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  2. Roger M. Brown
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Lal, H., Brown, R.M. A possible relationship between catecholamines and acute toxicity of desipramine. Psychopharmacologia 12, 354–357 (1968). https://doi.org/10.1007/BF00401414

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  • DOI: https://doi.org/10.1007/BF00401414

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