Summary
Acute toxicity of desipramine in mice was shown to be influenced by other drugs. Pretreatment with reserpine but not with chlorpromazine, disulfiram, or p-chlorophenylalanine protected mice against desipramine toxicity. Reserpine protection was reversed by dopa or dopa and disulfiram but not by methyldopa or 5-hydroxytryptophan. These results suggested a relationship between catecholamines and desipramine toxicity.
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Lal, H., Brown, R.M. A possible relationship between catecholamines and acute toxicity of desipramine. Psychopharmacologia 12, 354–357 (1968). https://doi.org/10.1007/BF00401414
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DOI: https://doi.org/10.1007/BF00401414