Summary
This paper reports several studies of the effects of pentylenetetrazol on learning in mice. The first three studies indicated that, for several strains and learning tasks, the degree of facilitation produced by posttrial injections of subconvulsive doses of pentylenetetrazol varied with the different strains and experimental conditions used. The fourth experiment showed that facilitation of learning is obtained only when the drug is injected within 15 minutes before or after training. Other findings indicated that the convulsive and lethal doses of pentylenetetrazol depend upon the animals' deprivation state and that when given to rats in subconvulsive doses, the drug produces EEG effects which are seen within minutes after injection and which last for less than one hour. We interpret the results of these learning experiments as indicating that pentylenetetrazol enhances learning by affecting processes involved in memory storage.
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References
Bovet, D., J. L. McGaugh, and A. Oliverio: Effects of posttrial administration of drugs on avoidance learning. Life Sci. 5, 1309–1315 (1966).
—, F. Bovet-Nitti, and A. Oliverio: Effects of nicotine on avoidance conditioning of inbred strains of mice. Psychopharmacologia (Berl.) 10, 1–5 (1966).
Edwards, A. L.: Experimental design in psychological research. New York: Rinehart 1960.
Esplin, D. W., and D. M. Woodbury: The fate and excretion of C14 labeled pentylenetetrazol in the rat, with comments on analytical methods for pentylenetetrazol. J. Pharmacol. exp. Ther. 118, 129–138 (1956).
DeGroot, J.: The rat forebrain in stereotoxic coordinates. Amsterdam: North Holland Pub. Co. 1959.
Hudspeth, W. J.: Strychnine: its facilitating effect on the solution of a simple oddity problem by the rat. Science 145, 1331–1333 (1964).
Hunt, E. B., and J. Krivanek: The effects of pentylenetetrazol and methylphenoxypropane on discrimination learning. Psychopharmacologia (Berl.) 9, 1–16 (1966).
Krivanek, J., and E. B. Hunt: The effects of posttrial injections of pentylenetetrazol, strychnine, and mephenesin on discrimination learning. Psychopharmacologia (Berl.) 10, 189–195 (1967).
Longo, V. G.: Rabbit Brain Research, Vol. II: Electroencephalographic atlas for Pharmacological Research. Amsterdam: Elsevier 1962.
McGaugh, J. L.: Time-dependent processes in memory storage. Science 153, 1351–1358 (1966).
—, and L. Petrinovich: Effects of drugs on learning and memory. Int. Rev. Neurobiol. 8, 139–196 (1965).
—, C. W. Thomson, W. H. Westbrook, and W. J. Hudspeth: A further study of learning facilitation with strychnine sulphate. Psychopharmacologia (Berl.) 3, 352–360 (1962).
—, W. H. Westbrook, and G. S. Burt: Strain differences in the facilitating effects of 5-7-diphenyl-1-3-diazadamantan-6-ol (17571.S.) on maze learning. J. comp. physiol. Psychol. 54, 502–505 (1961).
Petrinovich, L.: Drug facilitation of learning: strain differences. Psychopharmacologia (Berl.) 10, 375–378 (1967).
Stratton, L. O., and L. Petrinovich: Posttrial injections of an anti-cholinesterase drug on maze learning in two strains of rats. Psychopharmacologia (Berl.) 5, 47–54 (1963).
Westbrook, W. H., and J. L. McGaugh: Drug facilitation of latent learning. Psychopharmacologia (Berl.) 5, 440–446 (1964).
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Krivanek, J., McGaugh, J.L. Effects of pentylenetetrazol on memory storage in mice. Psychopharmacologia 12, 303–321 (1968). https://doi.org/10.1007/BF00401409
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DOI: https://doi.org/10.1007/BF00401409