Summary
DBA/2J mice, susceptible to audiogenic seizures, were found to be more susceptible to pentylenetetrazol- and electrically-induced seizures than either C57BL/6J or F1 hybrid mice, which are resistant to audiogenic seizures. Reserpine increased susceptibility to both pentylenetetrazol and electroconvulsive seizures in C57BL/6J, DBA/2J and F1 hybrid mice. 5-hydroxytrptophan, iproniazid and amino-oxyacetic acid decreased seizure susceptibility in all groups of mice. These results were interpreted to mean that DBA/2J mice are more susceptible to seizures than C57BL/6J or F1 hybrid mice regardless of the agents used to induce the seizures, and that levels of 5-HT, NE and GABA are important in determining seizure thresholds.
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This research was supported by Research Grant MH-13026 from the National Institute of Mental Health.
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Schlesinger, K., Boggan, W.O. & Griek, B.J. Pharmacogenetic correlates of pentylenetetrazol and electroconvulsive seizure thresholds in mice. Psychopharmacologia 13, 181–188 (1968). https://doi.org/10.1007/BF00401398
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DOI: https://doi.org/10.1007/BF00401398