Abstract
The uptake and distribution of mercury in various organs and tissues of mice were examined after administration with mercuric chloride (HgCl2) or mercuric sulphide (HgS). The results show that mice treated with HgCl2 were found to have significantly higher levels of mercury in various organs and tissues as compared to HgS-treated animals. Except for the kidneys, no significant differences were found in mercury levels between the HgS-treated and control mice. This appears to be due to the higher solubility of HgCl2, allowing for its greater absorption into the body. Irrespective of the mercurial administered, the kidneys contained the highest concentration of mercury, followed by the liver and brain. Mercury was also found to confer protection against Trypanosoma evansi, possibly due to its toxicity. When treated with HgS, enhanced antibody production and increased levels of circulating leucocytes was seen. HgCl2 and HgS-treated mice showed no signs of anorexia, no significant changes being found in growth and food intake.
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References
Agemian, H. and Chau, A. S. H.: 1976, ‘An Improved Digestion Method for the Extraction of Mercury from Environmental Samples’, Analyst 101, 91–95.
Ashner, M.: 1987, ‘Changes in Axonally Transported Proteins in the Mature and Developing Rat Nervous System During Early Stages of Methylmercury Exposure’, Pharmacol. Toxicol. 60, 81–85.
Bidstrup, P. L.: 1964, Toxicity of Mercury and its Compounds, Elsevier Publishing Co., New York.
Blakely, B. R., Sisodia, C. S., and Mukker, T.-K.: 1980, ‘The Effect of Methylmercury, Tetraethyl Lead and Sodium Arsenite on the Humoral Immune Response in Mice’, Toxicol. Appl. Pharmacol. 52, 252–254.
Dieter, M. P., Luster, M. I., Boorman, G. A., Jameson, C. W., Dean, J. H., and Cox, J. W.: 1983, ‘Immunological and Biochemical Responses in Mice Treated with Mercuric Chloride’, Toxicol. Appl. Pharmacol. 68, 218–228.
Gainer, J. H.: 1977, ‘Effects of Heavy Metals and Deficiency of Zinc on Mortality Rates in Mice Infected with Encephalomyocarditis Virus’, Amer. J. Vet. Res. 38, 869–872.
Gaworski, C. L. and Sharma, R. P.: 1978, ‘The Effects of Heavy Metals and [3H]thymidine Uptake in Lymphocytes’, Toxicol. Appl. Pharmacol. 46, 305–313.
Koh, L. L., Wong, M. K., Ng, S. C. and Soh, S. M.: 1977, Mercury in Chinese Medicine, Technical Report 5. Institute of Natural Sciences, Nanyang University, Singapore.
Koller, L. D.: 1973, ‘Immunosuppression Produced by Lead, Cadmium and Mercury’, Amer. J. Vet. Res. 34, 1457–1458.
Koller, L. D.: 1980, ‘Immunotoxicology of Heavy Metals’, Int. J. Immunopharmacol. 2, 269–279.
Koller, L. D., Exon, J. H., and Arbogast, B.: 1977a, ‘Methylmercury: Effect on Serum Enzymes and Humoral Antibody’, J. Toxicol. Environ. Health 2, 115–123.
Koller, L. D., Exon, J. H., and Brauner, J. A.: 1977b, ‘Methylmercury: Decreased Antibody Formation in Mice’ Proc. Soc. Exp. Biol. Med. 155, 602–604.
Lawrence, D. A.: 1981, ‘Heavy Metal Modulation of Lymphocyte Activities’, Toxicol. Appl. Pharmacol. 57, 439–451.
Meister, A.: 1981, ‘On the Cycles of Glutathione Metabolism and Transport’, Curr. Top. Cell Reg. 18, 21–58.
Sin, Y. M., Lim, Y. F., and Wong, M. K.: 1983, ‘Uptake and Distribution of Mercury in Mice from Ingesting Soluble and Insoluble Mercury Compounds’, Bull. Environ. Contam. Toxicol. 31, 605–612.
Sin, W. C., Wong, M. K. and Sin, Y. M.: 1989, ‘Changes in Tissue Glutathione and Mercury Concentrations in Rats Following Mercuric Chloride Injection through the Hepatic Portal Vien’, Bull. Environ. Contam. Toxicol. 42, 942–948.
Sin, Y. M., Teh, W. F., and Wong, M. K.: 1989, ‘Absorption of Mercuric Chloride and Mercuric Sulphide and Their Possible Effects on Tissue Glutathione in Mice’, Bull. Environ. Contam. Toxicol. 42, 307–314.
Sumino, K., Hayakawa, K., Shibata, T., and Kitamura, S.: 1975, ‘Heavy Metals in Normal Japanese Tissues’, Arch. Environ. Health 30, 487–494.
Vallee, B. L. and Ulmer, D. D.: 1972, ‘Biochemical Effects of Mercury, Cadmium and Lead’ Annu. Rev. Biochem. 41, 91–128.
Yeoh, T. S., Lee, A. S., and Lee, H. S.: 1986, ‘Absorption of Mercuric Sulphide Following Oral Administration in Mice’, Toxicol. 41, 107–111.
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Ryan, D.M., Sin, Y.M. & Wong, M.K. Uptake, distribution and immunotoxicological effects of mercury in mice. Environ Monit Assess 19, 507–517 (1991). https://doi.org/10.1007/BF00401337
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DOI: https://doi.org/10.1007/BF00401337