Skip to main content

Spontaneous endocrine tumors in Sprague-Dawley rats

Summary

Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas. Multiple occurrence of these tumors was frequently observed. This study describes the morphology of these spontaneous endocrine tumors.

This is a preview of subscription content, access via your institution.

References

  • Andersson, P.: High incidence of chromophobe pituitary adenoma-like lesions in an inbred-Sprague-Dawley breeding rat colony. Acta Vet. Scand. 10, 111–117 (1969)

    PubMed  Google Scholar 

  • Ballards, H.S., Frame, B., Hartsock, R.J.: Familial multiple endocrine adenoma-peptic ulcer complex. Medicine 43, 481–516 (1964)

    PubMed  Google Scholar 

  • Boorman, G.A., van Noord, M.J., Hollander, C.F.: Naturally occurring medullary thyroid carcinoma in the rat. Arch. Path. 94, 35–41 (1972)

    PubMed  Google Scholar 

  • Carney, J., Aidam, C.J., Sizemore, G.W., Sheps, S.G.: Adrenal Medullary disease in multiple endocrine neoplasia, type 2, pheochromocytoma and its precursors. Am. J. Clin. Pathol. 66, 279–290 (1976)

    PubMed  Google Scholar 

  • Catalona, W.J., Engelman, K., Ketcham, A.S., Hammond, W.G.: Familial medullary thyroid carcinoma, pheochromocytoma, and parathyroid adenoma (Sipple's syndrom). Cancer 28, 1245–1254 (1971)

    PubMed  Google Scholar 

  • Crain, R.C.: Spontaneous tumors in the Rochester strain of the Wistar rat. Am. J. Pathol. 34, 311–355 (1958)

    PubMed  Google Scholar 

  • Curtis, M.R., Bullock, F.D., Dunning, W.F.: Statistical study of the occurrence of spontaneous tumors in a large colony of rats. Am. J. Cancer 15, 67–121 (1931)

    Google Scholar 

  • DeLellis, R.A., Balogh, K.: Histochemical characteristics of parafollicular cells and medullary thyroid carcinoma. Am. J. Pathol. 72, 119–128 (1973)

    PubMed  Google Scholar 

  • Ezrin, C., Murray, S.: The cells of the human adenohypophysis in pregnancy, thyroid and adrenal cortical disorders. In: Cytology de l'adenohypophyse, Benoit, J., DaLage, C. (eds.), pp. 183–199. Paris: CNRS 1963

    Google Scholar 

  • Fleischmann, W.: Spontaneous endocrine diseases in laboratory animals. In the pathology of laboratory animals. Ribelin, W.E., McCoy, J.R. (eds.), pp. 60–92. Springfield (Illinois): Thomas, C.C. 1951

    Google Scholar 

  • Furth, J., Nakane, P.K., Pasteels, J.L.: Tumors of the pituitary gland. In the pathology of tumors in laboratory animals. Vol. 1, Tumors of the rats (part 2), Turusov, V.S. (ed.), pp. 201–237. Lyon: International Agency for Research on Cancer, 1976

    Google Scholar 

  • Gillman, J., Gilbelt, C., Spence, I.: Pheochromocytoma in the rat; pathogenesis and collateral reactions and its relation to comparable tumors in man. Cancer 6, 494–511 (1953)

    PubMed  Google Scholar 

  • Gomori, G.: Aldehyde fuchsin: a new stain for elastic tissue. Am. J. Clin. Pathol. 20, 665–666 (1950)

    PubMed  Google Scholar 

  • Grimelius, L.: A silver nitrate stain for α2 cell in human pancreatic islets. Acta Soc. Med. Upsal. 73, 243–270 (1968)

    PubMed  Google Scholar 

  • Hollander, C.F., Snell, K.C.: Tumors of the adrenal gland. In the pathology of tumors in laboratory animals. Vol. 1, Tumors of the rats (part 2), Turusov, V.S. (ed.), pp. 239–271. Lyon: International Agency for Research on Cancer 1976

    Google Scholar 

  • Ito, A., Moy, P., Kortwright, K., Clarke, S., Furth, J., Meites, J.: Incidence and character of the spontaneous pituitary tumors in strain CR and W/Fu male rats. J. Natl. Cancer Inst. 49, 701–711 (1972)

    PubMed  Google Scholar 

  • Jacob, B.B., Huseby, R.A.: Neoplasms occurring in aged Fisher rats with special reference to testicular, uterine, and thyroid tumors. J. Natl. Cancer Inst. 39, 303–309 (1967)

    Google Scholar 

  • Lindsay, S., Nichols, C.W. Jr., Chaikoff, I.L.: Naturally occurring thyroid carcinoma in the rat: Similarities to human medullary carcinoma. Arch. Path. 86, 353–364 (1968)

    Google Scholar 

  • Ljungberg, O., Cederquist, E., Standnitz, W.: Medullary thyroid carcinoma and pheochromocytoma: A familial chromaffinomatosis. Br. Med. J. 1, 279–281 (1967)

    PubMed  Google Scholar 

  • Maekawa, A., Odashima, S.: Spontaneous tumors in ACI/N rats. J. Natl. Cancer. Inst. 55, 1437–1445 (1975)

    PubMed  Google Scholar 

  • Napalkov, N.P.: Tumors of the thyroid gland: In the pathology of tumors in laboratory animals. Vol. 1, Tumors of the rats (part 2), Turusov, V.S. (ed.), pp. 239–271, Lyon: International Agency for Research on Cancer 1976

    Google Scholar 

  • Prejean, J.D., Peckham, J.C., Casey, D.P., Weisburger, E.K., Weisburger, I.H.: Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res, 33, 2768–2773 (1973)

    PubMed  Google Scholar 

  • Roe, F.J.C., Roberts, J.D.B.: Tumors of the pancreas. In the pathology of tumors in laboratory animals. Vol. 1, Tumors of the rats (part 1), Turusov, V.S. (ed.), pp. 141–150. Lyon: International Agency for Research on Cancer 1973

    Google Scholar 

  • Rosen, V.J., Castanera, T.J., Kimeldorf, D.J., Jones, D.C.: Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. Lab. Invest. 11, 204–210 (1962)

    PubMed  Google Scholar 

  • Rowlatt, U.: Spontaneous epithelial tumors of the pancreas of mammals. Br. J. Cancer 21, 82–107 (1967)

    PubMed  Google Scholar 

  • Saxton, J.A. Jr., Graham, J.B.: Chromophobic adenoma-like lesions of the rats hypophysis. Cancer Res. 4, 168–178 (1944)

    Google Scholar 

  • Sipple, J.H.: Association of pheochromocytoma with carcinoma of thyroid gland. Am. J. Med. 31, 163–166 (1961)

    Article  Google Scholar 

  • Thompson, S.W., Huseby, R.A., Fox, M.R., Davis, C.L., Hunt, R.D.: Spontaneous tumors in the Sprague-Dawley rat. J. Natl. Cancer Inst. 27, 1037–1057 (1961)

    PubMed  Google Scholar 

  • Thompson, S.W., Hunt, R.D.: Spontaneous tumors in the Sprague-Dawley rat: Incidence rates of some type of neoplasms as determined by serial section versus single section technics. Ann. NY Acad. Sci. 108, 832–845 (1963)

    Google Scholar 

  • Wermer, P.: Genetic aspects of adenomatosis of endocrine gland. Am. J. Med. 16, 363–371 (1954)

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This work was supported by Alexander von Humboldt-Foundation

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Suzuki, H., Mohr, U. & Kimmerle, G. Spontaneous endocrine tumors in Sprague-Dawley rats. J. Cancer Res. Clin. Oncol. 95, 187–196 (1979). https://doi.org/10.1007/BF00401012

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00401012

Key words

  • Spontaneous endocrine tumors
  • Sprague-Dawley rats
  • Multiple endocrine tumors