Summary
The antitumor activity of imidazolium-bisimidazole-tetrachlororuthenate (III) against the P388 leukemia and against the B16 melanoma was investigated.
The test compound showed high activity against these tumor models. The tumor inhibiting effect was in the range or better than the effects of the compounds cyclophosphamide, cisplatin, or 5-fluorouracil, which were tested as positive controls.
The effective substance is a new, water soluble, anionic, nitrogen-heterocyclic coordinated, ruthenium species, exhibiting antitumor activity.
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Dedicated to Professor Dietrich Schmähl on the occasion of his 60th birthday
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Keppler, B.K., Rupp, W. Antitumor activity of imidazolium-bisimidazole-tetrachlororuthenate (III). J Cancer Res Clin Oncol 111, 166–168 (1986). https://doi.org/10.1007/BF00400758
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DOI: https://doi.org/10.1007/BF00400758