Summary
The protein designated as insulin receptor substrate-1 (IRS-1) is a major substrate for the insulin receptor tyrosine kinase. Since post-receptor defects in the insulin signalling pathway are a common feature of Type 2 (non-insulin-dependent) diabetes mellitus, we have cloned the human IRS-1 gene in order to study the role of genetic variation in this gene in the pathogenesis of diabetes mellitus. As a first step in these studies, we have mapped the IRS-1 gene to chromosome 2, bands q35–q36.1 and identified a simple tandem repeat DNA polymorphism in this gene that will be useful for genetic studies.
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Stoffel, M., Espinosa, R., Keller, S.R. et al. Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism. Diabetologia 36, 335–337 (1993). https://doi.org/10.1007/BF00400237
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DOI: https://doi.org/10.1007/BF00400237