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Electron-microscopic study on liver cells of rats treated with actinomycin D

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Summary

Actinomycin D was administered to rats. The animals were also given either cytidine-3H or leucine-3H. Light microscopic radioautography revealed decreased labelling of nucleolar and cytoplasmic RNA and, after high doses, also of chromatin RNA. The protein labelling was not diminished, except perhaps in the nucleoli. Electron-microscopic investigations revealed pronounced changes in the nucleoli, which became compact. Discrete changes were sometimes seen in other parts of the nuclei.

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Authors and Affiliations

  1. Department of Pathology, University of Uppsala, Sweden

    Unne Stenram

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  1. Unne Stenram
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Additional information

The investigation was supported by a research grant (project No. W 337) from the Swedish Medical Research Council.

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Stenram, U. Electron-microscopic study on liver cells of rats treated with actinomycin D. Zeitschrift für Zellforschung 65, 211–219 (1964). https://doi.org/10.1007/BF00400117

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  • DOI: https://doi.org/10.1007/BF00400117

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