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Monooxygenase activity of human epithelial cells (HeLa): Comparison of the response to treatment by arylhydrocarbons and diterpene esters

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Summary

Arylhydrocarbons are inducers of monooxygenase activity in epithelial cells in culture (Hela) whereas diterpene esters are not. This is one more example of a specific biochemical difference — here in gene activation — exhibited by tumor initiators and tumor promoters of the classes of compounds assayed.

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Abbreviations

TPA:

12-O-tetradecanoylphorbol-13-acetate

4-OMe-TPA:

4-O-methyl-12-O-tetradecanoylphorbol-13-acetate

P2 :

1α-alkyldaphnane-type orthoester (Adolf et al. 1982)

3-TI:

3-tetradecanoyl-ingenol

DMBA:

7,12-dimethylbenz(a)anthracene

BA:

benz(a)antracene

DMSO:

dimethylsulfoxide

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Authors and Affiliations

  1. Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, Federal Republic of Germany

    Walter G. Pyerin

  2. Institut für Biochemie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, Federal Republic of Germany

    Erich Hecker

Authors
  1. Walter G. Pyerin
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  2. Erich Hecker
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Pyerin, W.G., Hecker, E. Monooxygenase activity of human epithelial cells (HeLa): Comparison of the response to treatment by arylhydrocarbons and diterpene esters. J Cancer Res Clin Oncol 106, 71–73 (1983). https://doi.org/10.1007/BF00399901

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  • DOI: https://doi.org/10.1007/BF00399901

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