Summary
To study the effect of chronic alcohol consumption on tumor development due to dimethylnitrosamine (DMN) administration, female Sprague-Dawley rats were pair-fed for 3 weeks a nutritionally adequate liquid diet containing either ethanol (36% of total calories) or isocalorically substituted carbohydrates as control diet. Thereafter, the animals were maintained on laboratory chow and tap water ad libitum for another 2 weeks and received 1.5 mg DMN i.p. per day for the first 5 days. This 5-week cycle was repeated three more times. Chronic treatment with an alcohol-containing diet was shown to significantly improve the mean survival time of DMN-treated rats compared with identically treated animals fed the control diet, but the total number of tumors observed under these experimental conditions and the target organ remained virtually unchanged.
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Abbreviations
- DMN:
-
dimethylnitrosamine
- DEN:
-
diethylnitrosamine
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Teschke, R., Minzlaff, M., Oldiges, H. et al. Effect of chronic alcohol consumption on tumor incidence due to dimethylnitrosamine administration. J Cancer Res Clin Oncol 106, 58–64 (1983). https://doi.org/10.1007/BF00399898
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DOI: https://doi.org/10.1007/BF00399898