Summary
The carcinogenicity of N-carboxymethyl-N-nitrosourea (CMNU), a naturally occurring N-nitroso compound, was tested in female Donryu rats. Four groups of female Donryu rats were given 400, 200, 100, or 0 ppm of CMNU solution continuously as drinking water. The incidence of tumors was highest and the mean survival time shortest in the 400 ppm group. A dose-effect relationship was observed in the tumor incidence and the mean survival time and the incidences of tumors in all experimental groups were significantly different from those in the control group. In the 400 ppm group, tumors were detected most frequently in the small intestine, followed by the mammary gland. In contrast, most tumors were observed in the mammary gland in the other two experimental groups, although dose-dependent induction of tumors of the small intestine was also detected in these two groups. The organ specificity of CMNU is compared with that of other N-alkyl-N-nitrosourea derivatives.
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Supported by a Grant in-aid for cancer research from the Ministry of Education, Science, and Culture. Part of this study was presented at the 41st Annual Meeting of the Japanese Cancer Association held in Osaka in August 1982.
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Maekawa, A., Ogiu, T., Matsuoka, C. et al. Induction of tumors in the small intestine and mammary gland of female Donryu rats by continuous oral administration of N-carboxymethyl-N-nitrosourea. J Cancer Res Clin Oncol 106, 12–16 (1983). https://doi.org/10.1007/BF00399891
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DOI: https://doi.org/10.1007/BF00399891