Antibacterial activity of Δ9-tetrahydrocannabinol and cannabidiol

Abstract

The minimum inhibiting concentrations (MIC) of Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) for staphylococci and streptococci in broth are in the range of 1–5 μg/ml. In the same range, both compounds are also bactericidal. In media containing 4% serum or 5% blood the antibacterial activity is strongly reduced (MIC 50μg/ml). Gram-negative bacteria are resistant to THC and CBD.

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References

  1. Agurell, S., Nilsson, I. M., Ohlsson, A. and Sandberg, F. 1970. On the metabolism of tritium-labelled Δ1-tetrahydrocannabinol in the rabbit. — Biochem. Pharmacol. 19: 1333–1339.

    Google Scholar 

  2. Ferenczy, L., Gracza, L. and Jacobey, I. 1958. An antibacterial preparatum from Hemp (Cannabis sativa L.). — Naturwissenschaften 45: 188.

    Google Scholar 

  3. Gal, I. E., Vayda, O. and Bekes, I. 1969. Investigation of certain properties of cannabidiolic acid from the aspect of food preservation. (In Hungarian) — Élelmiszervizsgalati Közlem. 4: 208–216. (From Chem. Abstr. 72 (1970): 88976t).

    Google Scholar 

  4. Garrett, E. R. and Hunt, C. A. 1974. Physicochemical properties, solubility, and protein binding of Δ9-tetrahydrocannabinol. — J. Pharm. Sci. 63: 1056–1064.

    Google Scholar 

  5. Kabelik, J. 1957. Hanf (Cannabis sativa) — Antibiotisches Heilmittel. 1. Mitteilung: Hanf in der Alt- und Volksmedizin. — Pharmazie 12: 439–443.

    Google Scholar 

  6. Krejči, Z. 1958. Hanf (Cannabis sativa) — Antibiotisches Heilmittel. 2. Mitteilung: Methodik und Ergebnisse der bakteriologischen Untersuchungen und vorläufige klinische Erfahrungen. — Pharmazie 13: 155–166.

    Google Scholar 

  7. Schultz, O. E. and Haffner, G. 1959. Zur Kenntnis eines sedativen und antibakteriellen Wirkstoffes aus dem deutschen Faserhanf (Canabis sativa). — Z. Naturforschg. 14b: 98–100.

    Google Scholar 

  8. Steers, E., Folts, E. L. and Graves, B. S. 1959. Inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. — Antibiot. Chemother. 9: 307–311.

    Google Scholar 

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van Klingeren, B., ten Ham, M. Antibacterial activity of Δ9-tetrahydrocannabinol and cannabidiol. Antonie van Leeuwenhoek 42, 9–12 (1976). https://doi.org/10.1007/BF00399444

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Keywords

  • Antibacterial Activity
  • Minimum Inhibit Concentration
  • Inhibit Concentration
  • Minimum Inhibit Concentration
  • Cannabidiol