Antonie van Leeuwenhoek

, Volume 42, Issue 1–2, pp 9–12 | Cite as

Antibacterial activity of Δ9-tetrahydrocannabinol and cannabidiol

  • B. van Klingeren
  • M. ten Ham
Physiology and Growth


The minimum inhibiting concentrations (MIC) of Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) for staphylococci and streptococci in broth are in the range of 1–5 μg/ml. In the same range, both compounds are also bactericidal. In media containing 4% serum or 5% blood the antibacterial activity is strongly reduced (MIC 50μg/ml). Gram-negative bacteria are resistant to THC and CBD.


Antibacterial Activity Minimum Inhibit Concentration Inhibit Concentration Minimum Inhibit Concentration Cannabidiol 
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Copyright information

© H. Veenman en Zonen 1976

Authors and Affiliations

  • B. van Klingeren
    • 1
  • M. ten Ham
    • 2
  1. 1.Laboratory for ChemotherapyNational Institute of Public HealthBilthovenThe Netherlands
  2. 2.Laboratory for PharmacologyNational Institute of Public HealthBilthovenThe Netherlands

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