Summary
Tumor samples from 74 patients with gynecologic malignancies including breast cancer were processed in a soft agar colony-forming assay. None of the samples resulted in a pure single cell suspension. Of the 10 samples meeting our criteria of evaluability for chemosensitivity testing, only 5 samples showed in vitro sensitivity to any drug. Of the 3 evaluable correlations between in vitro and in vivo results, 2 were correct. Due to the low rate of evaluable samples the assay has only limited value in the assignment of chemotherapeutic drugs for patients treated at our institution.
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This work was supported in part by the Gesellschaft zur Bekämpfung der Krebskrankheiten Nordrhein-Westfalen
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Umbach, G.E., Poethen, J., Matthiessen, H.v. et al. Experiences with the human tumor colony-forming assay in gynecologic malignancies. J Cancer Res Clin Oncol 110, 234–237 (1985). https://doi.org/10.1007/BF00399280
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DOI: https://doi.org/10.1007/BF00399280