Summary
The present study describes the estrogen receptor (ER) detection by an immunocytochemical assay kit (ER-ICA) on cryostat sections of 78 primary breast carcinomas. Results are compared with quantitatively measured ER levels, which were obtained by the dextran-coated charcoal (DCC) method. An excellent overall correlation between the logarithm of the ER levels, estimated by this technique, and the semiquantitative immunocytochemical evaluation was found, i.e. r=0.73. Since the ER-ICA can be easily handled without radioactivity being involved and since it is more representative of the total tumor, we conclude (as other groups before us) that the ER-ICA is an easy-to-handle and reliable technique presenting many advantages over the DCC method.
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Dedicated to Prof. Dr. H.-G. Hillemanns on his 65th birthday
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von Kleist, S., Berling, J., Koltzenburg, J. et al. Estrogen receptor determinations in primary breast cancer. J Cancer Res Clin Oncol 114, 623–627 (1988). https://doi.org/10.1007/BF00398188
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DOI: https://doi.org/10.1007/BF00398188