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15/17 Translocation in acute promyelocytic leukaemia

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Summary

A translocation between a chromosome 15 and a chromosome 17 was found in the bone marrow of a 14-year-old boy who had clinical and laboratory symptoms of acute promyelocytic leukemia (APL). As far as we know, this is the sixth case of APL with 15/17 translocation to be reported in the literature. This observation gives further support to the hypothesis that there is an association between this chromosomal rearrangement and APL.

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References

  • Colomb, H. M., Rowley, J., Vardiman, J., Baron, J., Locker, G., Krasnow, S.: Partial deletion of long arm of chromosome 17. Arch. Intern. Med. 136, 825–828 (1976)

    Google Scholar 

  • Kaneko, Y., Sakurai, M.: 15/17 translocation in acute promyelocytic leukaemia. Lancet 1977I, 961

  • Lawler, S. D., Secker Walker, L. M., Summersgill, B. M., Reeves, B. R., Lewis, J., Kay, H. E. M., Hardisty, R. M.: Chromosome banding studies in acute leukaemia at diagnosis. Scand. J. Haematol. 15, 312–320 (1975)

    Google Scholar 

  • Mitelman, F., Nilsson, P. G., Levan, G., Brandt, L.: Non-random chromosome changes in acute myeloid leukaemia. Chromosome banding examination of 30 cases at diagnosis. Int. J. Cancer 18, 31–38 (1976)

    Google Scholar 

  • Okada, M., Miyazaki, T., Kumota, K.: 15/17 translocation in acute promyelocytic leukaemia. Lancet 1977I, 961

  • Rowley, J. D., Golomb, H. M., Dougherty, C.: 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia. Lancet 1977aI, 549–550

  • Rowley, J. D., Golomb, H. M., Vardiman, J., Fukuhara, S., Dougherty, C., Potter, D.: Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukaemia. Int. J. Cancer 20, 869–872 (1977b)

    Google Scholar 

  • Rowley, J. D. Potter, D.: Chromosomal banding patterns in acute nonlymphocytic leukaemia. Blood 47, 705–721 (1976)

    Google Scholar 

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Authors and Affiliations

  1. Department of Human Genetics, Division of Cytogenetics, University of Nijmegen, The Netherlands

    J. M. J. C. Scheres, T. W. J. Hustinx & F. J. Rutten

  2. Department of Pediatrics, Oncology Unit, Faculty of Medicine, University of Nijmegen, The Netherlands

    G. A. M. de Vaan

Authors
  1. J. M. J. C. Scheres
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  2. T. W. J. Hustinx
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  3. G. A. M. de Vaan
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  4. F. J. Rutten
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Scheres, J.M.J.C., Hustinx, T.W.J., de Vaan, G.A.M. et al. 15/17 Translocation in acute promyelocytic leukaemia. Hum Genet 43, 115–117 (1978). https://doi.org/10.1007/BF00396488

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  • DOI: https://doi.org/10.1007/BF00396488

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