Summary
The lymphocyte chromosomes from 23 children with the ‘fetal alcohol syndrome’ or ‘alcohol embryopathy’ (AE) were analyzed with respect to exchange type aberrations. These aberrations were not more frequent in AE than in controls. The possibility that AE results from unspecific suppression of RNA and consequently of protein synthesis in the developing embryo is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Atwood, K. C.: Some aspects of the bobbed problem in Drosophila. Genetics [Suppl.] 61, 319–327 (1969)
Cohen, F., Zuelzer, W., Gustavson, D. C., Evans, M. M.: Mechanisms of isoimmunization. I. The transplacental passage of fetal erythrocytes in homospecific pregnancies. Blood 23, 621–641 (1964)
Dudin, G., Beek, B., Obe, G.: The human leukocyte test system. I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures. Mutat. Res. 23, 279–281 (1974)
Große, K.-P., Schwanitz, G., Rott, H.-D., Wißmüller, H. F.: Chromosomenuntersuchungen bei Behandlung mit Anticonyulsiva. Humangenetik 16, 209–216 (1972)
Grouchy, J. de, Trébuchet, C.: Transfusion foeto-maternelle de lymphocytes sanguins et détection du sexe du fetus. Ann. Genet. (Paris) 14, 133–137 (1971)
Jellinek, E. M.: Phases in the drinking history of alcoholics: Analysis of a survey conducted by the official organ of A. A. Q.. J. Stud. Alcohol 7, 1–88 (1946)
Jones, K. L., Smith, D. W.: Recognition of the fetal alcohol syndrome in early infancy. Lancet 1973 II, 999–1001
Jones, K. L., Smith, D. W., Streissguth, A. P., Myrianthopoulos, N. C.: Outcome in offspring of chronic alcoholic women. Lancet 1974 I, 1076–1078
Jones, K. L., Smith, D. W., Ulleland, C. N., Streissguth, A. P.: Pattern of malformation in offspring of chronic alcoholic mothers. Lancet 1973 I, 1267–1271
Kesäniemi, Y. A.: Ethanol and acetaldehyde in the milk and peripheral blood of lactating women after ethanol adminsstration. J. Obstet. Gynecol. Br. Commonw. 81, 84–86 (1974)
Kesäniemi, Y. A., Sippel, H. W.: Placental and foetal metabolism of acetaldehyde in rat. I. Contents of ethanol and acetaldehyde in placenta and foetus of the pregnant rat during ethanol oxidation. Acta Pharmacol. Toxicol. 37, 43–48 (1975)
Lemoine, P., Harousseau, H., Borteyru, J. P., Menuet, J. C.: Les enfants de parents alcooliques anomalies abservées, à propos de 127 cas. Quest. Med. 25, 477–482 (1968)
Majewski, F.: Über schädigende Einflüsse des Alkohols auf die Nachkommen. Nervenarzt (in press, 1978)
Majewski, F., Bierich, J. R., Löser, H., Michaelis, R., Leiber, B., Bettecken, F.: Zur Klinik und Pathogenese der Alkoholembryopathie (Bericht über 68 Patienten). Münch. Med. Wochenschr. 118, 1635–1642 (1976)
Majewski, F., Bierich, J. R., Seidenberg, J.: Zur Häufigkeit und Pathogenese der Alkoholembryopathie. Monatsschr. Kinderheilkd. 126, 284–285 (1978)
Obe, G., Herha, J.: Chromosomal damage in chronic alcohol users. Humangenetik 29, 191–200 (1975)
Obe, G., herha, J.: Chromosomal aberrations in heavy smokers. Hum. Genet. 41, 259–263 (1978)
Obe, G., Ristow, H.: Acetaldehyde, but not ethanol, induces sister chromatid exchanges in Chinese hamster cells in vitro. Mutat. Res. 56, 211–213 (1977)
Obe, G., Ristow, H., Herha, J.: Chromosomal damage by alcohol in vitro and in vivo. In: Alcohol intoxication and withdrawal-IIIa, M. M. Gross, ed., pp. 47–70. New York: Plenum Press Adv. Exp. Med. Biol. 85A, 1977
Obe, G., Ristow, H., Herha, H.: The effect of alcohol on chromosomal structure and function. In: Pharmacology of ethanol, E. Majchrowicz, E. P. Noble, eds. New York: Plenum 1977 (in preparation)
Pikkarainen, P. H., Räihä, N. C. R.: Development of alcohol dehydrogenase activity in the human liver. Pediatr. Res. 1, 165–168 (1967)
Ritossa, F. M., Scala, G.: Equilibrium variations in the redundancy of rDNA in Drosophila melanogaster. Genetics [Suppl.] 61, 305–317 (1969)
Rawat, A. K.: Effect of maternal ethanol consumption on foetal and neonatal rat hepatic protein synthesis. Biochem. J. 160, 653–661 (1976)
Samaille-Villette, Ch., Samaille, P. P.: Le syndrome d'alcoolisme foetal. Journ. Nationales Neonatal. Paris 1977, 37–43 (1977)
Tillner, I., Majewski, F.: Furrows and dermal ridges of the hand in patients with alcohol embryopathy. Hum. Genet. 42, 307–314 (1978)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Obe, G., Majewski, F. No elevation of exchange type aberrations in lymphocytes of children with alcohol embryopathy. Hum Genet 43, 31–36 (1978). https://doi.org/10.1007/BF00396475
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00396475