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Gastrointestinal food allergy and its role in large domestic animals

Abstract

The significance of food allergy as a primary cause for gastrointestinal disturbances in domestic animals, especially calves and piglets, is discussed. The immunological backgrounds and pathogenesis are described in some detail. The clinical and pathological manifestations in animals are related to those in man. Diagnostic possibilities, therapy and prevention, as far as known in animals, are mentioned and, based on human experiences, further extensions are proposed.

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References

  • AtkinsF. M. & MetcalfeD. D., 1984. The diagnosis and treatment of food allergy. Ann. Rev. Nutr., 4, 233–255

    Google Scholar 

  • AmlotP. L., UrbanekR., YoultenL. J. F., KemenyM. & LessofM. H., 1985. Type I allergy to egg and milk proteins: comparison of skin prick tests with nasal, buccal and gastric provocation tests. Int. Archs. Allergy Appl. Immun., 77, 171–173

    Google Scholar 

  • BarrattM. E. J. & PorterP., 1979. Immunoglobulin classes implicated in intestinal disturbances of calves associated with soya protein antigens. J. Immunol., 123, 676–680

    Google Scholar 

  • BarrattM. E. J., StrachanP. J. & PorterP., 1978. Antibody mechanisms implicated in digestive disturbances following ingestion of soya protein in calves and piglets. Clin. Exp. Immunol., 31, 305–312

    Google Scholar 

  • BlochK. J., LakeA. M., SinclairK. & WalkerW. A., 1981. IgE-mediated alterations in intestinal permeability and mucus release. In: P. L.Ogra & J.Bienenstock (eds), The mucosal immune system in health and disease. Report of the eighty-first Ross conference on pediatric research, (Ross Laboratories, Columbus, Ohio), 109–114

    Google Scholar 

  • BockS. A. & MayC. D., 1981. True manifestations of sensitivity reactions to food and the associated immunologic findings. In: P. L.Ogra & J.Bienenstock (eds), The mucosal immune system in health and disease. Report of the eighty-first Ross conference on pediatric research, (Ross Laboratories, Columbus, Ohio), 114–118

    Google Scholar 

  • BrandtzaegP., 1985. Research in gastrointestinal immunology. State of the art. Scand. J. Gastroenterol., 20 (supplement 114), 137–156

    Google Scholar 

  • BusincoL., BenincoriN., & CantaniA., 1984. Epidemiology, incidence and clinical aspects of food allergy. Ann. Allergy, 53, 615–622

    Google Scholar 

  • BusincoL. & CantaniA., 1984. Prevention of atopy—current concepts and personal experience. Clin. Rev. Allergy, 2, 107–123

    Google Scholar 

  • CoombsR. R. A. & McLaughlanP., 1984. Allergenicity of food proteins and its possible modification. Ann. Allergy, 53, 592–596

    Google Scholar 

  • DukorP., KallósP., SchlumbergerH. D. & WestG. B., 1980. Introduction. In: P.Dukor, P.Kallós, H. D.Schlumberger & G. B.West (eds), PAR. Pseudo-allergic reactions. Involvement of drugs and chemicals, vol. 1: genetic aspects and anaphylactoid reactions, (Karger, Basel), ix-xiv

    Google Scholar 

  • EadeO. E. & WrightR., 1976. Dietary hypersensitivity: a gastroenterologist's view. J. Hum. Nutr., 30, 157–163

    Google Scholar 

  • EasthamE. J. & WalkerW. A., 1979. Adverse effects of milk formula ingestion on the gastrointestinal tract. Gastroenterology, 76, 365–374

    Google Scholar 

  • EgbertsH. J. A., BrinkhoffM. G. M., MouwenJ. M. V. M., DijkJ. E.van & KoninkxJ. F. J. G., 1985. Biology and pathology of the intestinal M-cell. A review. Vet. Quart., 7, 333–336

    Google Scholar 

  • EgbertsH. J. A., KoninkxJ. F. J. G., DijkJ. E.van & MouwenJ. M. V. M., 1984. Biological and pathobiological aspects of the glycocalyx of the small intestinal epithelium. A review. Vet. Quart., 6, 186–199

    Google Scholar 

  • ElsonC. O., 1985. Induction and control of the gastrointestinal immune system. Scand. J. Gastroenterol., 20 (supplement 114), 1–15

    Google Scholar 

  • FarahD. A., CalderJ., BensonL., & MackenzieJ. F., 1985. Specific food intolerance: its place as a cause of gastrointestinal symptoms. Gut, 26, 164–168

    Google Scholar 

  • FergusonA. C., 1984. Food allergy. Prog. Food Nutr. Sci., 8, 77–107

    Google Scholar 

  • FergusonA., MowatA. & LoganR. F. A., 1981. Mucosal cell-mediated immunity to dietary antigens. In: P. L.Ogra & J.Bienenstock (eds), The mucosal immune system in health and disease. Report of the eighty-first Ross conference on pediatric research. (Ross Laboratories, Columbus, Ohio), 128–134

    Google Scholar 

  • FisherS. E., MarkowitzJ. & LifshitzF., 1984. Food intolerance in childhood. Compreh. Therapy, 10, 5–11

    Google Scholar 

  • FleddérusA., DijkJ. E.van, MouwenJ. M. V. M. & HolzhauerC., 1985. Prevention of intestinal disturbances using disodium cromoglycate in veal calves. Vet. Rec., 117, 583–583

    Google Scholar 

  • ForgetP., ArendsJ. W. & ZandvoortR.van, 1985. Immunoglobuline E in dunne darmmucosa; een kwantitatieve analyse. Tijdschr. Kindergeneesk., 53, 56–59

    Google Scholar 

  • HarmsH. K., 1982. Die Kuhmilcheiweissabhängige Darmkrankheit des jungen Säuglings, eine Form der Kuhmilchproteinintoleranz. Klin. Pädiat., 194, 375–380

    Google Scholar 

  • HillD. J., FordR. P. K., SheltonM. J. & HoskingC. S., 1984. A study of 100 infants and young children with cow's milk allergy. Clin. Rev. Allergy, 2, 125–142

    Google Scholar 

  • HolzelA., 1975. Cow's milk allergy—some clinical and immunological aspects. Postgrad. Med. J., 51 (supplement 3), 71–75

    Google Scholar 

  • JewellD. P. & PatelC., 1985. Immunology of inflammatory bowel disease. Scand. J. Gastroenterol., 20 (supplement 114), 119–126

    Google Scholar 

  • KallósP. & KallósL., 1980. Histamine and some other mediators of pseudo-allergic reactions. In: P.Dukor, P.Kallós, H. D.Schlumberger & G. B.West (eds), PAR. Pseudo-allergic reactions. Involvement of drugs and chemicals, vol. 1 (Karger, Basel), 28–55

    Google Scholar 

  • KallósP. & KallósL., 1982. Pseudo-allergic reactions due to disodium cromoglycate. In: P.Dukor, P.Kallós, H. D.Schlumberger & G. B.West (eds), PAR. Pseudo-allergic reactions. Involvement of drugs and chemicals, vol. 3: Cell mediated reactions. Miscellaneous topics, (Karger, Basel), 122–132

    Google Scholar 

  • KatzA. J., TwarogF. J., ZeigerR. S. & FalchukZ. M., 1984. Milk-sensitive and eosinophilic gastroenteropathy: Similar clinical features with contrasting mechanisms and clinical course. J. Allergy Clin. Immunol., 74, 72–78

    Google Scholar 

  • KerenD. F., 1980. Immunology and immunopathology of the gastrointestinal tract. (Educational products division, Amer. Soc. of Clinical Pathologists, Chicago), 61–73, 96–102

    Google Scholar 

  • Kilshaw, P. J., 1981. Gastrointestinal hypersensitivity in the preruminant calf. In: F. J. Bourne (ed), The mucosal immune system. Current topics in veterinary medicine and animal science, 12, 203–223

  • KilshawP. J. & SissonsJ. W., 1979a. Gastrointestinal allergy to soyabean protein in preruminant calves. Antibody production and digestive disturbances in calves fed heated soyabean flour. Res. Vet. Sci., 27, 361–365

    Google Scholar 

  • KilshawP. J. & SissonsJ. W., 1979b. Gastrointestinal allergy to soyabean protein in preruminant calves. Allergenic constituents of soyabean products. Res. Vet. Sci., 27, 366–371

    Google Scholar 

  • KilshawP. J. & SladeH., 1980. Passage of ingested protein into the blood during gastrointestinal hypersensitivity reactions: experiments in the preruminant calf. Clin. Exp. Immunol., 41, 575–582

    Google Scholar 

  • KilshawP. J. & SladeH., 1982. Villus atrophy and crypt elongation in the small intestine of preruminant calves fed with heated soyabean flour or wheat gluten. Res. Vet. Sci., 33, 305–308

    Google Scholar 

  • KuitunenP., VisakorpiJ. K., SavilahtiE. & PelkonenP., 1975. Malabsorption syndrome with cow's milk intolerance. Clinical findings and course in 54 cases. Arch. Dis. Child., 50, 351–356

    Google Scholar 

  • LessofM. H., 1983. Food intolerance and allergy—a review. Quarterly J. Med., 52, 111–119

    Google Scholar 

  • LiuH. Y., GidayZs. & MooreB. F., 1977. Possible pathogenetic mechanisms producing bovine milk protein inducible malabsorption: a hypothesis. Ann. Allergy, 39, 1–7

    Google Scholar 

  • MarshM. N., 1985. Functional and structural aspects of the epithelial lymphocyte, with implications for coeliac disease and tropical sprue. Scand. J. Gastroenterol., 20 (supplement 114), 55–75

    Google Scholar 

  • McDonaldP. J., GoldblumM., SickleG. J. & PowellG. K., 1984. Food protein induced enterocolitis: altered antibody response to ingested antigen. Pediatr. Res., 18, 751–755

    Google Scholar 

  • MillerB. G., NewbyT. J., StokesC. R., HampsonD. & BourneF. J., 1983. The role of dietary antigen in the aetiology of post weaning diarrhoea. Annl. Rech. Vet., 14, 487–492

    Google Scholar 

  • MillerB. G., NewbyT. J., StokesC. R. & BourneF. J., 1984. Influence of diet on post weaning malabsorption and diarrhoea in the pig. Res. Vet. Sci., 36, 187–193

    Google Scholar 

  • MinfordA. M. B., MacDonaldA. & LittlewoodJ. M., 1982. Food intolerance and food allergy in children: a review of 68 cases. Arch. Dis. Child., 57, 742–747

    Google Scholar 

  • MouwenJ. M. V. M., EgbertsH. J. A. & KoninkxJ. F. J. G., 1983. The outermost mucosal barrier of the mammalian small intestine. Dtsch. Tierärztl. Wschr., 90, 477–482

    Google Scholar 

  • MowatA. McI., 1984. The immunopathogenesis of food-sensitive enteropathies. In: T. J.Newby & C. R.Stokes (eds), Local immune responses of the gut, (CRC Press., Boca Raton, Florida), 199–225

    Google Scholar 

  • NewbyT. J., MillerB., StokesC. R. & BourneF. J., 1983. Hypersensitivity to dietary antigens as the predisposing factor in post-weaning diarrhoea. Pig Veter. Soc. Proceed., 10, 50–58

    Google Scholar 

  • PahudJ. J. & SchwarzK., 1984. Research and development of infant formulae with reduced allergenic properties. Ann. Allergy, 53, 609–614

    Google Scholar 

  • PanushR. S. & WebsterE. M., 1985. Food allergies and other adverse reactions to foods. Med. Clin. North. Am., 69, 533–546

    Google Scholar 

  • ParishW. E., 1983. Intolerance and allergy to foods and food additives: its relevance to toxicology. In: D. M.Conning & A. B. G.Lansdown (eds), Toxic hazards in food, (Croom Helm Ltd., London & Canberra), 22–72

    Google Scholar 

  • PearceF. L., BefusA. D., GauldieJ. & BienenstockJ., 1982. Mucosal mast cells. II. Effects of anti-allergic compounds on histamine secretion by isolated intestinal mast cells. J. Immunol., 128, 2481–2486

    Google Scholar 

  • PerkkiöM., SavilahtiE. & KuitunenP., 1981. Semi-quantitative analysis of immunoglobulins and complement fractions 3 and 4 in the jejunal mucosa in coeliac disease and in food allergy in childhood. Acta. path. microbiol. Scand. Sect. A., 89, 343–350

    Google Scholar 

  • PerlmanF., 1980. Allergens. In: J. E.Liener (ed), Toxic constituents of plant foodstuffs, (Academic Press, New York), 295–327

    Google Scholar 

  • PorterP., AllenW. D., BarrattM. E. J., DavisP. J. & LinggoodM. A., 1984. Relationships between the immune system and intestinal disease. In: R. M.Batt & T. L. J.Lawrence (eds), Function and dysfunction of the small intestine, (Liverpool University Press, Liverpool), 133–148

    Google Scholar 

  • ReimannH. J., RingJ., UltschB. & WendtP., 1985. Intragastral provocation under endoscopic control (IPEC) in food allergy: mast cell and histamine changes in gastric mucosa. Clin. Allergy, 15, 195–202

    Google Scholar 

  • RoittJ. M., BrostoffJ. & MaleD. K., 1985. Immunology (Gower Medical Publishing Ltd., London), ch. 4, 8, 10, 19

    Google Scholar 

  • RoyJ. H. B., 1984. Dietary sensitivities in the calf. In: R. M.Batt and T. L. J.Lawrence (eds), Function and dysfunction of the small intestine, (Liverpool University Press, Liverpool), 95–132

    Google Scholar 

  • SavilahtiE., 1973. Immunochemical study of the malabsorption syndrome with cow's milk intolerance. Gut, 14, 491–501

    Google Scholar 

  • SelbekkB. H., 1979. The effect of disodium cromoglycate on in vitro mast cell degranulation in human jejunal mucosa. Allergy, 34, 283–288

    Google Scholar 

  • SelbekkB. H., 1985. A comparison between in vitro jejunal mast cell degranulation and intragastric challenge in patients with suspected food intolerance. Scand. J. Gastroenterol., 20, 299–303

    Google Scholar 

  • Sissons, J. W., Pedersen, H. E. & Wells, K., 1984. Mucosal morphology in the alimentary tract of calves given heated soya bean flour. Proceed. Nutr. Soc., 43, 113A

    Google Scholar 

  • SissonsJ. W. & SmithR. H., 1976. The effect of different diets including those containing soyabean products, on digesta movement and water and nitrogen absorption in the small intestine of the pre-ruminant calf. Br. J. Nutr., 36, 421–438

    Google Scholar 

  • SissonsJ. W., SmithR. H. & HewittD., 1982. Prediction of the suitability of soya bean products for feeding to preruminant calves by an in-vitro immunochemical method. Br. J. Nutr., 47, 311–318

    Google Scholar 

  • SoothillJ. F., 1984. Prevention of food allergic disease. Ann. Allergy, 53, 689–691

    Google Scholar 

  • SpreeuwelJ. P.van, LindemanJ., MaanenJ.van & MeyerC. J. L. M., 1984. Increased numbers of IgE containing cells in gastric and duodenal biopsies. an expression of food allergy secondary to chronic inflammation? J. Clin. Pathol., 37, 601–606

    Google Scholar 

  • StefaniniG. F., BazzocchiG., PratiE., LanfranchiG. A. & GasbarriniG., 1986. Efficacy of oral disodium cromoglycate in patients with irritable bowel syndrome and positive skin prick tests to foods (letter). Lancet, 8474, 207–208

    Google Scholar 

  • SternM., DietrichR. & MüllerJ., 1982. Small intestinal mucosa in coeliac disease and cow's milk protein intolerance: morphometric and immunofluorescent studies. Eur. J. Pediatr., 139, 101–105

    Google Scholar 

  • Stokes, C. R., Newby, T. J., Miller, B. G. & Bourne, F. J., 1984. The induction of gut damage as a result of a transient immune hypersensitivity to dietary antigens. Proceed. Nutr. Soc., 43, 117A

    Google Scholar 

  • SutantoA. H., 1982. Cow's milk protein sensitive enteropathy. Clinical and histological features in infants. Paed. Indones., 22, 65–69

    Google Scholar 

  • TaylorK. B., 1975. Alimentary and gastrointestinal allergy. In: L.van derReis (ed), Immune disorders. Front. gastrointest. res., 1 (Karger, Basel), 1–11

    Google Scholar 

  • VellengaL., MouwenJ. M. V. M., DijkJ. E.van & BreukinkH. J., 1985. Biological and pathological aspects of the mammalian small intestinal permeability to macromolecules. Vet. Quart., 7, 322–332

    Google Scholar 

  • VisakorpiJ. K., 1980. Nahrungsmittelintoleranz in Säuglingsalter. Monatsschr. Kinderheilkd., 128, 166–169

    Google Scholar 

  • VitoriaJ. C., CamareroC., SolagurenR., AranjueloM., OliverosR., NavajasA. & Rodriguez-SorianoJ., 1979. Cow's milk protein-sensitive enteropathy. Clinical and histological results of the cow's milk provocation test. Helv. paediat. Acta, 34, 309–318

    Google Scholar 

  • WalkerW. A., 1981. Intestinal transport of macromolecules. In: L. R.Johnson (ed), Physiology of the gastrointestinal tract, (Raven Press, New York), 1271–1289

    Google Scholar 

  • Walker-SmithJ. A., FordR. P. K. & PhillipsA. D., 1984. The spectrum of gastrointestinal allergies of food. Ann. Allergy, 53, 629–636

    Google Scholar 

  • WeströmB. R., SvendsenJ., OhlssonB. G., TagessonC. & KarlssonB. W., 1984. Intestinal transmission of macromolecules (BSA and FITC-labelled dextrans) in the neonatal pig. Biol. Neonate., 46, 20–26

    Google Scholar 

  • WildersM. M., SminiaT. & JanseE. M., 1983a. Ontogeny of non-lymfoid and lymfoid cells in the rat gut with special reference to large mononuclear Ia-positive dendritic cells. Immunology, 50, 303–314

    Google Scholar 

  • WildersM. M., DrexhageH. A., WeltevredenE. F., MullinkH., DuyvestijnA. & MeuwissenG. M., 1983b. Large mononuclear Ia-positive veiled cells in Peyer's patches. I. Isolation and characterization in rat, guinea-pig and pig. Immunology, 48, 453–460

    Google Scholar 

  • WildersM. M., SminiaT., PleschB. E. C., DrexhageH. A., WeltevredenE. F. & MeuwissenS. G. M., 1983c. Large mononuclear Ia-positive veiled cells in Peyer's patches. II. Localization in rat Peyer's patches. Immunology, 48, 461–467

    Google Scholar 

  • Willemse, A., 1984. Investigations on canine atopic dermatitis. (Ph.D. Thesis, State University Utrecht).

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Van Dijk, J.E., Fledderus, A., Mouwen, J.M.V.M. et al. Gastrointestinal food allergy and its role in large domestic animals. Veterinary Research Communications 12, 47–59 (1988). https://doi.org/10.1007/BF00396403

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  • DOI: https://doi.org/10.1007/BF00396403

Keywords

  • Public Health
  • Veterinary Medicine
  • Food Allergy
  • Domestic Animal
  • Human Experience