Summary
The modifying effect of an aromatic retinoic acid analog, Tigason, alone or in a combined regimen with selenium on the incidence of colon tumors induced by 1,2-dimethylhydrazine was investigated in BD rats. Treatment with the carcinogen alone resulted in induction of colon adenocarcinomas in 29 rats (92%). In comparison to the 1,2-dimethylhydrazinetreated group, administration of Tigason or Tigason plus selenium reduced tumor incidence (71% and 68%, respectively). The effect of combined treatment with Tigason and selenium, however, was not additive. Although some researchers have been unable to demonstrate any protective effect of different synthetic retinoids against 1,2-dimethylhydrazine or N-methyl-N-nitrosourea-induced colon tumors, our findings suggest that the process of tumor initiation in colon mucosa can be significantly influenced by the aromatic retinoid Tigason or by simultaneous administration of Tigason and selenium.
This is a preview of subscription content, log in via an institution to check access.
References
Becci PJ, Thompson HJ, Grubbs CJ, Squire R, Brown CC, Sporn MB, Moon RC (1978) Inhibitory effect of 13-cis-retinoid acid on urinary bladder carcinogenesis induced in C57BL/6 mice by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res 38:4463–4466
Bollag W (1975) Prophylaxis of chemically induced epithelial tumors with an aromatic retinoic acid analog (Ro 10-9359). Eur J Cancer 11:721–724
Daoud A, Griffin AC (1978) Effects of selenium and retinoic acid on the metabolism of N-acetylaminofluorene and N-hydroxyacetylamino-fluorene. Cancer Lett 5:231–237
Harbach PR, Swenberg JA (1981) Effects of selenium on 1,2-dimethylhydrazine metabolism and DNA alkylation. Carcinogenesis 2:575–580
Ip C, Ip MM (1981) Chemoprevention of mammary tumorigenesis by a combined regimen of selenium and vitamin A. Carcinogenesis 2:915–918
Mehta RG, Moon RC (1980) Inhibition of DNA synthesis by retinyl acetate during chemically induced mammary carcinogenesis. Cancer Res 40:1109–1111
Miyata Y, Nakatsuka T, Arai M, Murasaki G, Nakanishi K, Ito N (1980) Inhibition by an aromatic retinoid of DNA damage induced by the bladder carcinogen N-butyl-N-3(carboxypropyl)-nitrosamine. Gann 71:341–348
Murasaki G, Miyata Y, Babaya K, Arai M, Fukushima S, Ito N (1980) Inhibitory effect of an aromatic retinoic acid analog on urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl(nitrosamine. Gann 71:333–340
Narisawa T, Reddy B, Wong CQ, Weisburger JH (1976) Effect of vitamin A deficiency on rat colon carcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine. Cancer Res 36:1379–1383
Port CD, Sporn MB, Kaufman DG (1975) Prevention of lung cancer in hamsters by 13-cis-retinoic acid. Proc Am Assoc Cancer Res 16:21
Raina V, Gurtoo HL (1985) Effects of vitamins A, C, and E on aflatoxin B1-induced mutagenesis in Salmonella typhimurium TA-98 and TA-100. Teratogenesis Carcinog Mutagen 5:29–40
Rogers AE, Herdon BJ, Newberne PM (1973) Induction by dimethylhydrazine of intestinal carcinoma in normal rats and rats fed high or low levels of vitamin A. Cancer Res 33:1003–1009
Silverman J, Katayama S, Zelenakas K, Lauber J, Musser TK, Reddy M, Levenstein MJ, Weisburger JH (1981) Effect of retinoids on the induction of colon cancer in F344 rats by N-methyl-N-nitrosourea or by 1,2-dimethylhydrazine. Carcinogenesis 2:1167–1172
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hadjiolov, D., Grueva, D. Effect of combined tigason and selenium treatment on colon carcinogenesis. J Cancer Res Clin Oncol 112, 285–286 (1986). https://doi.org/10.1007/BF00395926
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00395926