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DNA adducts and cell cycle

  • Original Papers
  • Experimental Oncology
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Summary

Cell cycle-dependent differences of transformation sensitivity may be due to alterations in the formation of ultimate electrophilic carcinogens during the cell cycle, preferential primary adduct formation during specific phases of the cell cycle, e.g. binding to single stranded DNA at the replication fork, base-mispairing and mutation of transformation-related genes replicating at critical phases of DNA synthesis, or cell cycle-related differences in the repair of DNA adducts. Some recent data on these subjects are summarized, mainly in context of cell cycle-dependent transformation sensitivity of regenerating rat liver.

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Authors and Affiliations

  1. Institute of Pathology, University of Munich, Thalkirchener Straße 36, D-8000, München 2, Federal Republic of Germany

    Hartmut M. Rabes

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  1. Hartmut M. Rabes
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Original work was supported by Deutsche Forschungsgemeinschaft and Dr.-Mildred-Scheel-Stiftung für Krebsforschung

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Rabes, H.M. DNA adducts and cell cycle. J Cancer Res Clin Oncol 112, 189–195 (1986). https://doi.org/10.1007/BF00395911

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  • DOI: https://doi.org/10.1007/BF00395911

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