Abstract
Sera of 33 hominide primates (Pan 12, Gorilla 6, Pongo 11, Symphalangus 4) have been examined for the presence of the group specific components (Gc) by agar-gel immunoelectrophoresis.
With the use of anti-human-Gc-horsesera Gc-globulins were demonstrated in all 33 sera of the four hominide primate species. Gc phenotypes of Pongo and of Gorilla were indistinguishable from human Gc phenotypes. In Pongo the types Gc 1-1, Gc 2-1 and Gc 2-2 have been observed, in Gorilla only the type Gc 1-1 has been found. The Gc phenotype in sera of Pan and Symphalangus was found to be different from the Gc phenotypes in Man. This Gc-type is probably determined by a specific Gc allele, for which the notation Gcape has been given.
With three different anti-human-Gc-sera reaction of immunologic identity has been demonstrated between the human Gc and the Gc of the four hominide primate species.
Zusammenfassung
Es wurden die Seren 33 anthropoider Affen (Pan 12, Gorilla 6, Pongo 11, Symphalangus 4) mit der Agargel-Immunoelektrophorese auf das Vorkommen von „group specific components” untersucht.
Bei allen anthropoiden Affen konnten wir Gc-Globuline mit Anti-Human-Gc-Pferdeseren nachweisen. Bei Pongo und bei Gorilla sind die Gc-Phänotypen „hominid” geprägt. Bei Pongo fanden sich die Gc-Typen Gc 1-1, Gc 2-1 und Gc 2-2, bei Gorilla fand sich der Typ Gc 1-1. Der bei Pan und Symphalangus fefundene Gc-Typ steht außerhalb des Gc-Systems von Homo; er wird vermutlich durch ein eigenes Allel kontrolliert, das wir mit Gcape bezeichnen.
Mit drei verschiedenen Anti-Human-Gc-Seren erwiesen sich die Gc-Globuline der anthropoiden Affen immunologisch mit denen des Menschen identisch.
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Literatur
Cleve, H.: Populationsgenetik des Gc-Systems. Homo (im Druck).
— and A. G. Bearn: Inherited variations in human serum proteins; studies on the group specific component. Ann. N. Y. Acad. Sci. 94, 218–224 (1961).
——: The group specific component of serum; genetic and chemical considerations. Progr. med. Genet. 2, 64–82 (1962).
— R. L. Kirk, W. C. Parker, A. G. Bearn, L. E. Schacht, H. Kleinman, and W. R. Horsfall: Two genetic variants of the group specific component of human serum: Gc Chippewa and Gc Aborigine. Amer. J. hum. Genet. 15, 368–379 (1963).
— J. H. Prunier, and A. G. Bearn: Isolation and partial characterization of the two principal inhertied group specific components of human serum. J. exp. Med. 118, 711–726 (1963).
Gahne, B.: Inherited variations in the post-albumins of cattle serum. Hereditas (Lund) 50, 126–135 (1963).
Hess, N., u. R. Bütler: Untersuchungen über die Gc Gruppen von Hirschfeld. Schweiz. med. Wschr. 92, 1351–1352 (1962).
Hirschfeld, J.: Immune-electrophoretic demonstration of qualitative differences in human sera and their relation to the haptoglobins. Acta path. microbiol. scand. 47, 160–168 (1959).
—: Individual precipitation patterns of normal rabbit sera. Acta path. microbiol. scand. 46, 224–238 (1959).
—: The Gc-system. Immuno-electrophoretic studies of normal human sera with special reference to a new genetically determined serum system (Gc). Progr. Allergy 6, 155–186 (1962).
— B. Jonsson, and M. Rasumson: Inheritance of a new group specific system demonstrated in normal human sera by means of an immuno-electrophoretic technique. Nature (Lond.) 185, 931–932 (1960).
Jenssen, W.: Untersuchungen zur Genetik der gruppen-spezifischen Komponente (Gc). Naturwiss. Diss., München 1962.
Nerstrom, B.: On the inheritance of the Gc-system. A Danish family study. Acta genet. (Basel) 13, 30–43 (1963).
Ouchterlony, Ö: Antigen-antibody reactions in gels. Acta path. microbiol. scand. 26, 507–515 (1949).
Parker, W. C., H. Cleve, and A. G. Bearn: Determination of phenotypes in the human-group-specific component (Gc) system by starch gel electrophoresis. Amer. J. hum. Genet. 15, 353–367 (1963).
Prunier, J. H., A. G. Bearn, and H. Cleve: Site of formation of the group-specific component and certain other serum proteins. Proc. Soc. exp. Biol. (N. Y.) 115, 1005–1007 (1963).
Reinskou, T., and J. Mohr: Inheritance of the Gc types: 95 Norwegian families with 343 children. Acta genet. (Basel) 12, 51–55 (1962).
Scheidegger, J. J.: Une micro-méthode de l'immuno-électrophorèse. Int. Arch. Allergy 7, 103–110 (1955).
Schultze, H. E., H. Biel, H. Haupt u. K. Heide: Über die Gc-Komponenten von Hirschfeld. II. Darstellung und Eigenschaften. Naturwissenschaften 49, 108 (1962).
Wendt, G. G., u. U. Theile: Untersuchungen über den Gc Faktor. Dtsch. med. Wschr. 88, 696–701 (1963).
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Schmitt, J., Ensgraber, A., Krüpe, M. et al. Die Gc-Erbmerkmale im Serum der anthropoiden Affen. Humangenetik 1, 289–295 (1965). https://doi.org/10.1007/BF00395659
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DOI: https://doi.org/10.1007/BF00395659