Summary
The attenuation coefficients of cerebral parenchyma and systemic blood were simultaneously measured at varying times after injection of two contrast agents with differing osmolarities. Cerebral parenchyma was in fact denser than the theory would predict. The osmolarity of the iodinated contrast agents seems to play only a very minor part. However, liposolubility could perhaps explain the leakage of iodine across the BBB and thus the increase in the attenuation coefficient of cerebral parenchyma.
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Caillé, J. M., Constant, P., Billerey, J., Renou, A. M.: Variations in the measurement of regional cerebral blood volume. Comput. Tomogr. CAT 2 (in press 1978)
Fenstermacher, J. D., Johnson, J. A.: Filtration and repletion coefficients of the rabbit blood-brain barrier. Am. J. Physiol. 211, 341–346 (1966)
Fenstermacher, J. D., Patlak, C. S.: The movements of water and solutes in the brains of mammals. In: Dynamics of brain edema, pp. 87–94 (eds. H. M. Pappius, W. Feindel). Berlin-Heidelberg-New York: Springer 1976
Gado, M. H., Eichling, J., Higgins, C., Currie, M.: The study of CBV by CAT and a comparison with other methods. Computerised axial tomography in clinical practice. 1st European seminar, pp. 272–279 (eds. G. H. du Boulay, I. F. Moseley). Berlin-Heidelberg-New York: Springer 1977
Gonsette, R.: Incidence clinique des troubles de la perméabilité capillaire cérébrale. Paris: Masson 1972
Jeppsson, Olin, T.: Cerebral distribution of contrast medium and paradoxical location of lesions of the blood-brain barrier in the rabbit. Acta Radiol. [Diagn.] (Stockh.) 16, 577–584 (1975)
Ladurner, G., Zilka, E., Iliff, L. D., Du Boulay, G. H., Marshall, J.: Measurement of regional cerebral blood volume by computerized axial tomography. J. Neurol. Neurosurg. Psychiatry 39, 152–158 (1976)
Levin, E., Tradatti, C. E.: Bypass of the blood-brain barrier to proteins without brain tissue damage. In: Dynamics of brain edema, pp. 23–27 (eds. H. M. Pappius, W. Feindel). Berlin-Heidelberg-New York: Springer 1976
Levitan, H., Rapoport, S. I.: Contrast media: Quantitative criteria for designing compounds with low toxicity. Acta Radiol. [Diagn.] (Stockh.) 17, 81–92 (1976)
Phelps, M. E., Kuhl, D. E.: Pitfalls in the measurement of cerebral blood volume with computed tomography. Radiology 121, 375–377 (1976)
Rapoport, S. I.: Experimental modification of blood brain barrier permeability by hypertonic solutions, convulsions, hypercapnia, and acute hypertension. In: Fluid environment of the brain, pp. 61–80 (eds. H. F. Cserr et al.). New York: Academic 1975
Rapoport, S. I., Matthews, K., Thompson, H. K.: Absence of brain edema after reversible osmotic opening of the blood brain barrier. In: Dynamics of brain edema, pp. 18–22 (eds. H. M. Pappius, W. Feindel). Berlin-Heidelberg-New York: Springer 1976
Schanker, L. S.: Mechanisms of drug absorption. Annu. Rev. Pharmacol. 1, 29–44 (1961)
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Caillé, JM., Billerey, J., Renou, AM. et al. Cerebral blood volume and water extraction from cerebral parenchyma by hyperosmolar contrast media. Neuroradiology 16, 579–582 (1978). https://doi.org/10.1007/BF00395368
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DOI: https://doi.org/10.1007/BF00395368