Summary
The periodicity of the estrual cycle in mice was studied by vaginal cytology during the growth of a hormone-independent mammary adenocarcinoma. A direct relationship between age progression and lengthening of estrual cycle was observed in control mice but not in tumor-bearing mice of the same age. These results suggest that hormone regulation of the estrual cycle may be affected in tumor-bearing hosts.
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Vauthay, L.G., de Bonaparte, Y.P. Estrual cycle periodicity in hormone-independent tumor-bearing mice. J Cancer Res Clin Oncol 115, 449–450 (1989). https://doi.org/10.1007/BF00393335
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DOI: https://doi.org/10.1007/BF00393335