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Induction of diphtheria toxin-resistant mutants in human cells by halogenated compounds

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Summary

The mutagenic power of 1,2-dichloroethane, 1,2-dibromoethane, 1,2-diiodoethane was tested in the human cell line, EUE. In our mutagenic system, based on selection against diphtheria toxin, the halogenated compounds, 1,2-dichloroethane and 1,2-dibromoethane revealed a strong mutagenic effect, whereas 1,2-diiodoethane was not mutagenic at a concentration allowing survival of 41%.

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Abbreviations

DTr :

diphtheria toxin resistant

PBS:

phosphatebuffered saline

DT:

diphtheria toxin

Lf:

floculating unit

DMSO:

dimethyl sulfoxide

References

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Authors and Affiliations

  1. Istituto di Cancerologia, Università di Bologna, Viale Filopanti 22, I-40126, Bologna, Italy

    A. M. Ferreri, P. Rocchi, A. Capucci & G. Prodi

Authors
  1. A. M. Ferreri
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  2. P. Rocchi
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  3. A. Capucci
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  4. G. Prodi
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Additional information

This work was supported by a grant from Ministero della Sanità: “Piano di ricerca nel campo delle malattie sociali” No. 500.4/RSC/ 135/L/1209

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Ferreri, A.M., Rocchi, P., Capucci, A. et al. Induction of diphtheria toxin-resistant mutants in human cells by halogenated compounds. J Cancer Res Clin Oncol 105, 111–112 (1983). https://doi.org/10.1007/BF00391843

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  • DOI: https://doi.org/10.1007/BF00391843

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