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Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium(IV) compounds

A new class of antineoplastic agents

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Summary

The antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium(IV) compounds against L 1210 leukemia as compared with cis-diamminedichloroplatinum(II) (Cisplatin, cis-DDP, NSC 119875) was investigated. The tested compounds showed an enhanced effect and a lower toxicity compared with Cisplatin.

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References

  • Hill JM, Loeb E, MacLellan A, Hill NO, Khan A, King JJ (1975) Clinical studies of platinum coordination compounds in the treatment of various malignant diseases. Cancer Chemother Rep 59:647–659

    Google Scholar 

  • Köpf-Maier P, Hesse B, Köpf H (1980) Tumorhemmung durch Metallocene: Wirkung von Titanocen-, Zirkonocen- und hafnocendichlorid gegenüber Ehrlich-Ascites-Tumor der Maus. J Cancer Res Clin Oncol 96:43–51

    Google Scholar 

  • Madjos NE, Harrinston CT (1978) Platinum Nephrotoxicity. Am J Med 65: 307–314

    Google Scholar 

  • Pinedo HM (1979) Cancer chemotherapy. Excerpta Medica, Amsterdam Oxford pp 107–125

    Google Scholar 

  • Serpone N, Fay RC (1967) Stereochemistry and lability of dihalobis(β-diketonato)-titanium(IV) complexes, II benzoylacetonates and dibenzoylmethanates. Inorg Chem 6:1835–1843

    Google Scholar 

  • Speer RJ, Ridgway H, Hall LM, Stewart PD, Howe KE, Lieberman DZ, Newman AP, Hill JM (1975) Coordination complexes of platinum as antitumour agents. Cancer Chemother Rep 59:629–641

    Google Scholar 

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Keller, H.J., Keppler, B. & Schmähl, D. Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium(IV) compounds. J Cancer Res Clin Oncol 105, 109–110 (1983). https://doi.org/10.1007/BF00391842

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  • DOI: https://doi.org/10.1007/BF00391842

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