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The distribution and excretion of trivalent antimony in the rat following inhalation

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Summary

  1. 1.

    Two distribution-excretion studies were carried out on rats which had been allowed to inhale an aerosol of antimony-124 tri-chloride. Two rabbits and one dog were administered intratracheally of the same compound.

  2. 2.

    Results of the inhalation exposure show the typical rapid early loss from lung with somewhat exponential loss of longer biological half life (100 days) after the twentieth day. Serial sacrifice and tissue distribution indicated primary sites of antimony concentration other than lung to be whole blood, spleen, heart, and other highly vascularized tissues. On a long range or a continuous exposure basis, the “critical” organ based strictly upon an antimony concentration would be the circulating blood, and primarily the red blood cells.

  3. 3.

    The excretion data are not elaborate enough to enable a good clearcut bioassay procedure. It is obvious that simple relationships exist between the daily urinary and fecal antimony output and the existing body burden but these relationship were not determined from these studies. Whole body counting at a lapsed time after inhalation exposure to radioactive antimony isotopes apparently could be used as a method of estimating initial body burden (assuming such measurements could not be made at the time of exposure). After twenty days the body burden decreases (in the rat) according to a simple exponential function.

  4. 4.

    Altough antimony localizes greatly in red blood cells of the rat this is not evident in the rabbit or dog. Based upon these findings certain doubts arise concerning the extrapolation of rat data to man in such studies.

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Authors and Affiliations

  1. Institut za medicinu rada, Belgrad, Pasterova 14, Yugoslavia

    D. Djurić

  2. Section of Radiobiology, Lovelace Foundation, Albuquerque, New Mexico, USA

    R. G. Thomas &  R. Lie

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  1. D. Djurić
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  2. R. G. Thomas
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  3. R. Lie
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This paper is based on work performed under contract with the United States Atomic Energy Commission at the University of Rochester Atomic Energy Project, Rochester, New York, U. S. A.

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Djurić, D., Thomas, R.G. & Lie, R. The distribution and excretion of trivalent antimony in the rat following inhalation. Int. Arch. Gewerbepath. Gewerbehyg. 19, 529–545 (1962). https://doi.org/10.1007/BF00391679

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  • DOI: https://doi.org/10.1007/BF00391679

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