Summary
Five polymeric materials (3 polyvinyl chlorides, 1 polyhydroxyethyl methacrylate, and 1 dimethyl polysiloxane) were implanted into subcutaneous (SC) tissues of rats. Subcutaneous tumors developed in all experimental groups. The incidences of the tumors differed however, although the experimental conditions were the same for all these materials. This result indicates that chemical characteristics of the materials may influence the incidence of SC tumors. From the histological and electron-microscopic findings many of these tumors were diagnosed as malignant fibrous histiocytomas.
References
Bischoff F, Bryson G (1964) Careinogenesis through solid state surfaces. Prog Exp Tumor Res 5:85–133
Brand KG, Buoen LC, Johnson KH, Brand I (1975a) Etiological factors, stages, and the role of the foreign body in foreign-body tumorigenesis: A review, Cancer Res 35:279–286
Brand KG, Buoen LC, Brand I (1975b) Foreign-body tumorigenesis induced by glass and smooth and rough plastic: Comparative study of preneoplastic events. J Natl Cancer Inst 55:319–322
Carter RL (1973) Tumors of soft tissues. In: Pathology of tumors in laboratory animals, vol 1: Tumors of the rat, part 1. IARC, Lyon, pp 151–167
Carter RL, Roe FJC, Peto R (1971) Tumor induction by plastic films: Attempt to correlate carcinogenic activity with certain physicochemical properties of the implant. J Natl Cancer Inst 46:1277–1289
Druckrey H, Schmähl D (1952) Carcinogene Wirkung von Kunststoff-Folien. Z Naturforsch 75:353–361
Hueper WC (1964) Cancer induction by polyurethane and polysilicone plastics. J Natl Cancer Inst 33:1005–1025
Johnson KH, Ghobrial HKG, Buoen LC, Brand I, Brand KG (1973) Non-fibroblastic origin of foreign-body sarcomas implicated by histological and electron microscopical studies. Cancer Res 33:3139–3154
Kojima K, Imai Y, Masuhara E (1974) Reaction between poly (vinylalcohol) graft copolymers and tissue [in Japanese]. Artif Organs 3:443–448
Maekawa A, Ogiu T, Onodera H, Furuta K, Matsuoka C, Mochizuki M, Anjo T, Okada M, Odashima S (1982) Carcinogenicity of N-alkyl-N-(acetoxymethyl)nitrosamines after subcutaneous injections in F-344 rats. J Cancer Res Clin Oncol 104:13–21
Maekawa A, Onodera H, Tanigawa H, Furuta K, Kodama Y, Horiuchi S, Hayashi Y (1983) Neoplastic and non-neoplastic lesions in aging Slc: Wistar rats. J Toxicol Sci 8:279–290
Nothdurft H (1955) Über die Sarkomauslösung durch Fremdkörper-Implantation bei Ratten in Abhängigkeit von der Form der Implante. Naturwissenschaft 42:166
Nothdurft H, Mohr HJ (1958) Sarkomerzeugung mit Fensterglas. Naturwissenschaft 45:549
Oppenheimer BS, Oppenheimr ET, Stout AP (1948) Sarcomas induced in rats by implanting cellophane. Proc Soc Exp Biol Med 67:33–34
Oppenheimer BS, Oppenheimer ET, Danishefsky I, Stout AP, Eirich FR (1955) Further studies of polymers as carcinogenic agents in animals. Cancer Res 15:333–340
Stinson NE (1964) The tissue reaction induced in rats and guinea pigs by polymethylmethacrylate (acrylic) and stainless steel (18/8/Mo). Br J Exp Pathol 45:21–29
Turner FC (1941) Sarcomas at sites of subcutaneously implanted bakelite disks in rats. J Natl Cancer Inst 2:81–83
Watanabe A, Imai Y, Masuhara E (1978) Safety evaluation of poly-(vinylchloride) used in hemodialysis [in Japanese]. Artif Organs 7:179–180
Author information
Authors and Affiliations
Additional information
Supported by grants from the Science and Technology Agency of Japan
Rights and permissions
About this article
Cite this article
Maekawa, A., Ogiu, T., Onodera, H. et al. Malignant fibrous histiocytomas induced in rats by polymers. J Cancer Res Clin Oncol 108, 364–365 (1984). https://doi.org/10.1007/BF00390475
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00390475