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Specific lymphocyte transformation in murine malaria

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Summary

Lymphoblast transformation tests were performed on convalescent rats and mice, after infection with Plasmodium berghei had been reduced to latency. Spleen cells from immune animals reacted in vitro to specific plasmodial antigen and not to control antigen produced from non infected RBC. The response in vitro was dependent on the concentration of the antigen and the time of exposure to it. A correlation was observed between the parasitaemia of the convalescent animal during its acute infection and the reaction in vitro: the higher the parasitaemia the higher the in vitro stimulation.

Zusammenfassung

Lymphoblasten-Transformationsteste wurden an Ratten and Mäusen mit latenter Plasmodium berghei-Infektion ausgeführt.

Die Milzzellen von diesen immunisierten Tieren reagierten in vitro mit spezifischem Plasmodium-Antigen, jedoch nicht mit einem Kontrollantigen, das in nicht infizierten Erythrocyten produziert wurde.

Die Resultate dieses Tests in vitro waren von der Konzentration des Antigens und der Einwirkungszeit abhängig. Es wurde eine Korrelation der Parasitämie zwischen diesen Tieren während der akuten Infektion und der Reaktion in vitro festgestellt: Je höher die Parasitämie, desto höher die Stimulation in vitro.

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References

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Authors and Affiliations

  1. Department of Protozoology, Hebrew University, Hadassah Medical School, Jerusalem, Israel

    J. Golenser & D. T. Spira

  2. Department of Medical Parasitology, Catholic University, Nijmegen, The Netherlands

    J. P. Verhave & J. H. E. Th. Meuwissen

Authors
  1. J. Golenser
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  2. D. T. Spira
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  3. J. P. Verhave
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  4. J. H. E. Th. Meuwissen
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Additional information

This work was done as part of the International Collaborative Research Programme on Malaria Immunology and Immunopathology supported by the Dutch government

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Golenser, J., Spira, D.T., Verhave, J.P. et al. Specific lymphocyte transformation in murine malaria. Z. F. Parasitenkunde 50, 95–98 (1976). https://doi.org/10.1007/BF00389938

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  • DOI: https://doi.org/10.1007/BF00389938

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