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Delayed dermal hypersensitivity in Rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi

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Summary

Eighteen Rhesus monkeys were immunized with a fresh or lyophilized antigen preparation obtained from erythrocytes infected with Plasmodium knowlesi. Sixteen of these monkeys showed a positive delayed hypersensitivity response when subsequently skin tested with the immunizing antigen. Ten of the 16 positive reactors survived a P. knowlesi challenge, the remaining 6 showed several indications of protection. None of the 18 control monkeys gave a positive skin reaction or survived the challenging inoculum. Macro- and microscopical evidence suggests that the dermal reaction is of a delayed type.

Preliminary biochemical analysis of the antigen used in this experiment is included and its significance is discussed. Hematological data is also presented.

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Author notes

  1. Clarence A. Speer

    Present address: Department of Microbiology, University of Montana, 59801, Missoula, Mont., USA

  2. Robert H. Schenkel

    Present address: American Cyanamid, P. O. Box 400, 08540, Princeton, N.J., USA

Authors and Affiliations

  1. Department of Biology, University of New Mexico at Albuquerque, USA

    Edelberto J. Cabrera, Clarence A. Speer, Robert H. Schenkel, Mary L. Barr & Paul H. Silverman

Authors
  1. Edelberto J. Cabrera
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  2. Clarence A. Speer
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  3. Robert H. Schenkel
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  4. Mary L. Barr
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  5. Paul H. Silverman
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Additional information

Supported by the Agency for International Development, U.S. Department of State, Contract No. AID/csd-3689

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Cabrera, E.J., Speer, C.A., Schenkel, R.H. et al. Delayed dermal hypersensitivity in Rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi . Z. F. Parasitenkunde 50, 31–42 (1976). https://doi.org/10.1007/BF00389929

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  • DOI: https://doi.org/10.1007/BF00389929

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