Skip to main content
SpringerLink
Log in

Treatment of a patient with impaired renal function with gentamicin-PMMA-beads

  • Current Problem Case
  • Published:
Archives of orthopaedic and traumatic surgery Aims and scope Submit manuscript

Summary

150 Gentamicin-PMMA-beads were implanted (+ 160 mg gentamicin i.v. preop.) in a woman aged 73 years and with severely impaired kidney function. Frequent determination of gentamicin plasma concentrations and renal functions were possible. The plasma concentration reached a plateau at approx. 3 μg/ml. No accumulation of gentamicin in plasma occurred.

Zusammenfassung

150 Gentamycin-PMMA-Kugeln wurden implantiert (+ 160 mg Gentamicin i.v. preop.) in eine 73jährige Frau, die an einer starken Einschränkung der Nierenfunktionen litt. Relativ häufig wurden die Plasma-Konzentrationen vom Gentamycin und die renalen Funktionen bestimmt.

Die Konzentration von Gentamycin im Plasma erreichte einen Plateauwert von 3 μg/ml. Es trat keine Akkumulation von Gentamycin im Plasma auf.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Dettli L (1979) Pharmacokinetik des Gentamycins bei normaler und eingeschränkter Nierenfunktion. In: Gentamycin. Symposion Düsseldorf 1976. Urban und Schwarzenberg, München, S 32

    Google Scholar 

  • Lode H (1979) Aminoglycosid. Antibiotika im aktuellen Vergleich. Schattauer Verlag, Stuttgart, S 36

    Google Scholar 

  • Pabst J (1977) Berechnung der Serumkonzentrationen nach Implantation von Gentamycin-PMMA-Kugeln bei Patienten mit eingeschränkter Nierenfunktion. Internal Report of E Merck Nr 7/23/77

  • Vree TB, Hekster YA, Hafkenscheid JCM, Dalen R van, Friesen WT (1981) The influence of the urine flow on renal clearance of creatinine in patients with normal and impaired kidney function. Drug Intelligence and Clinical Pharmacy 15:194–198

    Google Scholar 

  • Wahlig H, Dingeldein R, Reuss K, Bergmann R (1978) The release of Gentamicin from polymethyl methacrylate beads. An experimental and pharmacokinetic study. J Bone Jt Surg 60-B:270–275

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopaedics, University of Nijmegen, The Netherlands

    G. H. I. M. Walenkamp

  2. Department of Clinical Pharmacy, St. Radboud Hospital, University of Nijmegen, The Netherlands

    T. B. Vree

Authors
  1. G. H. I. M. Walenkamp
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. B. Vree
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walenkamp, G.H.I.M., Vree, T.B. Treatment of a patient with impaired renal function with gentamicin-PMMA-beads. Arch. Orth. Traum. Surg. 99, 137–141 (1981). https://doi.org/10.1007/BF00389749

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00389749

Keywords

Search

Navigation