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Effects of 1,25-dihydroxycholecalciferol on fracture healing calcium, phosphate, and zinc in callus and serum

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Summary

The incorporation of calcium, phosphate, and zinc into the callus of closed tibial fractures was studied in adult rats fed a standard diet. Low doses (60ng/kg per day) of 1,25(OH)2D3 5 days a week greatly increased early callus mineralization. This was not related to an increased serum calcium-phosphate molar product but rather to a decreased ratio. The incorporation of zinc into callus seemed to be correlated to the mineralization process but not to the 1,25(OH)2D3 administration as such. The question of a direct, indirect, or a complex role of 1,25(OH)2D3 in bone formation and mineralization is discussed.

Zusammenfassung

Der Einbau von Kalzium, Phosphat und Zink in den Kallus bei geschlossenen Tibiafrakturen wurde an erwachsenen Ratten untersucht, die mit einer standardisierten Diät ernährt wurden. Niedrige Dosen (60 ng/kg pro Tag) von 1,25(OH)2D3 an 5 Tagen pro Woche haben die frühzeitige Mineralisation des Kallus bemerkenswert erhöht. Dies stand nicht in Zusammenhang mit einem erhöhten molaren Kalzium-Phosphat-Produkt, sondern eher mit einem herabgesetzten Verhältnis. Der Einbau von Zink schien mit der Mineralisation in Zusammenhang zu stehen, jedoch nicht mit der Verabreichung von 1,25(OH)2D3 als solcher. Die Frage einer direkten, indirekten oder komplexen Bedeutung von 1,25(OH)2D3 bei der Knochenbildung und der Mineralisation wird diskutiert.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, University of Umeå, S-90185, Umeå, Sweden

    O. Andreen & S. -E. Larsson

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  1. O. Andreen
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  2. S. -E. Larsson
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Andreen, O., Larsson, S.E. Effects of 1,25-dihydroxycholecalciferol on fracture healing calcium, phosphate, and zinc in callus and serum. Arch Orthop Trauma Surg 103, 257–262 (1984). https://doi.org/10.1007/BF00387331

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  • DOI: https://doi.org/10.1007/BF00387331

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