Abstract
8-hydroxyquinoline has been previously used as an inhibitor in studies on porphyrin metabolism, where it is thought to act by chelating iron. It is shown that this compound also rapidly inhibits uridine uptake of seedlings or cotyledons of the crucifer Matthiola incana R.Br. RNA synthesis is also affected but the inhibition is not as severe as reported for fission yeast.
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Abbreviations
- oligo (dT)-cellulose:
-
cellulose with oligo-deoxythymidylic acid attached
- poly (A):
-
polyadenylic acid
References
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Grierson, D., Hemleben, V. Effect of 8-hydroxyquinoline on the uptake of uridine and incorporation into RNA. Planta 134, 155–157 (1977). https://doi.org/10.1007/BF00384965
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DOI: https://doi.org/10.1007/BF00384965