Skip to main content
SpringerLink
Log in

Primary brain lymphoma. A brief review of clinical aspects and management

  • Neurooncology
  • Published:
Neurosurgical Review Aims and scope Submit manuscript

Abstract

Primary C.N.S. lymphoma is a rare tumor. Five such cases were treated in our clinic between January, 1991, and October, 1993. Four patients had tumor decompression and one had total resection. All of them received radiotherapy (radiation dose 40 Gy) and chemotherapy. One patient expired during the immediate postoperative period. Four patients showed a disappearance of the tumor on CT scan after the complete course of therapy of 9 months. Three patients showed recurrence intracranially at 15, 12, and 10 months. All patients died during follow up except one, who has been alive without recurrence for 10 months. Median survival was 13 months.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Berry MP, WJ Simpson: Radiation therapy in the management of primary malignant lymphoma of brain. Int J Radiat Oncol Biol Phy 7 (1981) 55–59

    Google Scholar 

  2. Boadle DJ, MHN Tatersal: Primary cerebral lymphoma presentation of eight cases and review of literature. Aust NZJ Med 19 (1989) 682–86

    Google Scholar 

  3. Bruni J, JM Bilbao, T Grog: Primary intramedullary malignant lymphoma of spinal cord. Neurology (Minncap) 27 (1977) 896–898

    Google Scholar 

  4. Burstein SD, JW Kernohan, A Uihlein: Neoplasms of reticuloendothelial system of the brain. Cancer 16 (1963) 289–305

    Google Scholar 

  5. Eby NL S Grufferman, CM Flannelly, SC Schold Jr, FS Vogel, PC Burger: Increasing incidence of primary brain lymphoma in the US. Cancer 62 (1988) 2461–2465

    Google Scholar 

  6. Ervin T, GP Canellos: Successful treatment of recurrent primary central nervous system Lymphoma with high dose methotrexate. Cancer 45 (1980) 1556–1557

    Google Scholar 

  7. Frank G, R Ferracinni, F Spagnolli: Primary intracranial Lymphomas. Surg Neurol 23 (1985) 3–6

    Google Scholar 

  8. Freeman C, JW Berg, SJ Cutler: Occurrence and prognosis of extranodal lymphomas. Cancer 29 (1972) 252–260

    PubMed  Google Scholar 

  9. Haerni-Simon G, JP Suchaud, H Eghbali, JM Coindre, B Haerni: Secondary involvement of central nervous system in malignant non hodgkin lymphomas. Oncology 44 (1987) 98–101

    Google Scholar 

  10. Hanberry JW, GS Dugger: Perithelial sarcoma of brain. A clinicopathological study of 13 cases. Arch Neurol 71 (1954) 732–761

    Google Scholar 

  11. Helle TL, RH Brilt, TV Colby: Primary lymphoma of the CNS: Clinicopathological study of experience at Stanford. J Neurosurgery 60 (1984) 94–103

    Google Scholar 

  12. Henry JM, RR Hefner Jr, SH Dillard, KM Earle, RL Davis: Primary malignant Lymphomas of CNS. Cancer 34 (1974) 1293–1302

    Google Scholar 

  13. Herbest KD, MP Gorden, GR Justice: Successful therapy with methotrexate of multicentric mixed lymphoma of CNS. Cancer 38 (1976) 1476–1478

    Google Scholar 

  14. Horvat B, C Pena, ER Fischer: Primary reticulum cell sarcoma (Microglioma) of brain. An electron microscopic study. Arch Pathology 87 (1969) 609–616

    Google Scholar 

  15. Jack CR, BP O'Neill Jr, PM Banks, DF Reese: Central nervous system lymphoma: histologic types and CT Appearence. Radiology 167 (1988) 211–215

    Google Scholar 

  16. Jellinger K, TH Radasklewicz, F Slowik: Primary malignant lymphoma of CNS in man. Acta Neuropatho (Berl) 6 (1975) 95–102

    Google Scholar 

  17. Lennert K: Malignant Lymphoma. New York Springer Verlag 1978: 83–110

    Google Scholar 

  18. Letendre L, PM Bbankss, DF Reessse, RH Miller, PW Scanlon, JM Kiely: Primary lymphoma of CNS Cancer 49 (1982) 439–943

    Google Scholar 

  19. Levy RM, DE Bredeen, ML Rosenblum: Neurological manifestations of AIDS. J Neurosurg 62 (1985) 475–495

    Google Scholar 

  20. Littman P, CC Wang: Reticulum cell sarcoma of brain, a review of literature and a study of 19 cases. Cancer 35 (1975) 1412–1420

    Google Scholar 

  21. Loeffler JS, TJ Ervin, P Mauch, A Skarin, HJ, Weinsterin GP Canellos, Cassady Jr: Primary lymphoma of central nervous system: Patterns of failure and factors that influence survival. J Clinical Oncol 3 (1985) 490–494

    Google Scholar 

  22. Mackintosh FR, TV Colgy, WJ Podolsky, JS Burke, RT Hoppe, FP Rosenfelt, SA Rosenberg, HS Kaplan: Central nervous system involvement in non hodgkin lymphomas: an analysis of 105 cases. Cancer 49 (1982) 586–595

    Google Scholar 

  23. Menchut MP, G Haberlord, MH Naheedy, FA Rubino: Long term survival of primary cerebral lymphoma with progressive radiation necrosis. Neurology 35 (1985) 552–556

    Google Scholar 

  24. Mendenhall NP, TL Tax, F Agree, B Harty Golder, WE Ballinger, RR Million: Primary lymphoma of CNS. CT scan characteristics and treatment results for 12 cases. Cancer 52 (1983) 1993

    Google Scholar 

  25. Miller DG: The association of immune diseases and malignant lymphoma. Ann Int Med 66 (1967) 507–521

    Google Scholar 

  26. Murray K, L Kun, J Cox: Primary malignant lymphoma of central nervous system: Results of treatment of 11 cases and review of literature. J Neurosurg 65 (1986) 600–607

    Google Scholar 

  27. Nelson DF, KL Martz, H Bonner, S Nelson Jamess, J Newall, HD Kerman, JW Thomson, KJ Murray: Non Hodgkins lymphoma of the brain. Can high dose large, volume radiation therapy improve survival? Report on a prospective trial by the radiation therapy oncology group (RTOG): RTOG 8315: Int J Radiat Oncol Bial Phys 23 (1973) 9–17

    Google Scholar 

  28. Neuwell EA, E Balaban, J Diehi, S Hill, E Frenkel: Successful treatment of primary central nervous system lymphomas with chemotherapy after osmotic blood brain barrier opening. Neurosurg 12 (1983) 662–627

    Google Scholar 

  29. O'Neili PB, JJ Illig: Primary central nervous system lymphoma. Mayo Clin Proc 64 (1989) 1005–1020

    Google Scholar 

  30. Povrekh HC, RR Sharma, PG Lynch, AJ Keogh, SS Prabbhu: Primary cerebral lymphoma: a report of 24 patients. Br J Neurosurgery 6 (1992) 563–573

    Google Scholar 

  31. Rappaport H: Tumours of the hemopoietic system. In: Atlas of tumour pathology. Sect 3 fasc 8. Washington DC, Armed Forces Institute of Pathology 1966

    Google Scholar 

  32. Rawlison DG, ME Billingham, PF Berry, RL Kempson: Cytology of CSF in patients with Hodgkin's disease or malignant lymphoma. Acta Neuropatho (Berl) 6 (1975) 187–191

    Google Scholar 

  33. Rosenblum ML, RM Levy, De Bredsen, W Soyt Wara, JL Ziegler: Primary central nervous system Lymphomas in patients with AIDS. Annals of Neurology 23 (1988) S13-S16

    Google Scholar 

  34. Schaumburg HH, CR Plank, RD Adams: The reticulum cell sarcoma-microglioma group of brain tumors. A consideration of their clinical features and therapy. Brain 95 (1972) 199–212

    Google Scholar 

  35. Schiffer D, A Chio, MT Giordana, D Novero, G Palestro, R Soffietti, E Vasario: Primary lymphomas of the brain: a clinicopathologic review of 37 cases. Tumori 73 (1987) 585–592

    Google Scholar 

  36. Shibamato Y, K Tsuktsui, Y Dodo, H Yamabe, N Shima, M Abe: Improved survival rate in primary intracranial lymphoma, treated by vincristine dixorubicin, cyclophosphamide, prednisolone chemotherapy. Cancer 65 (1990) 1907–1912

    Google Scholar 

  37. Spillane JA, BE Kendall, IF Mosley: Cerebral lymphoma: Clinical radiological correlation. J Neurol Neurosurg Psychiatry 45 (1982) 199–208

    PubMed  Google Scholar 

  38. Tallroth K, K Katevieo, U Anderson: Angiography and CT in the diagnosis of primary lymphoma of Brain. Clin Radiol 32 (1981) 383–388

    Google Scholar 

  39. The non Hodgkin's lymphoma Pathological classification project. The National cancer Institute sponsored study of classification on non Hodgkin's lymphoma. Summary and decription of working Formulation for clinical usage. Cancer 49 (1982) 2112–2139

    Google Scholar 

  40. Vaquero J, R Martinez, E Rossi, R Lopez: Primary cerebral lymphoma, the ‘ghost tumor’. Case report. J Neurosurg 60 (1984) 174–176

    Google Scholar 

  41. Watne K, H Scott, B Hager, MW Lindegarrd, O Notme, AF Abraham, H Hirenchberg: Primary lymphoma of brain. A report of 24 cases from the Norwegian Radium Hospital. Acta Oncologica 31 (1972) 545–550

    Google Scholar 

  42. Weingarten KL, RD Zimmermann, NE Leeds: Spontaneous regression of intra-cranial lymphoma. Radiology 149 (1983) 721–724

    PubMed  Google Scholar 

  43. Zimmermann HM: Malignant lymphomas of nervous system. Acta Neuro Pathol (suppl) (Berl) 6 (1975) 69–71

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Kartikeya Sharma & V. K. Jain

  2. Department of Radiotherapy, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Neeraj Rastogi & S. Hukku

  3. Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Ranjana Srivastva

Authors
  1. Kartikeya Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Neeraj Rastogi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ranjana Srivastva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. K. Jain
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Hukku
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sharma, K., Rastogi, N., Srivastva, R. et al. Primary brain lymphoma. A brief review of clinical aspects and management. Neurosurg. Rev. 18, 193–199 (1995). https://doi.org/10.1007/BF00383726

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00383726

Keywords

Search

Navigation