Summary
The purpose of the present study was to evaluate the relation between photographically assessed changes in eye redness and sensory eye irritation in 17 patients suffering from hayfever, provoked by increasing doses of birch pollen in the eye. Pre- and post-exposure diapositives were compared in a randomized and double blind design by a panel of five members. By evaluating the photographs we found a high reproducibility between panel members and for repeated evaluation by the individual panel member. Furthermore, we found that the photographic method was more sensitive for measurements of changes in eye redness than the observations normally performed during such conjunctival provocation tests. The correlations of the objective findings with the symptoms reported were good at high pollen doses, but at lower doses of birch pollen (about half the effective dose) a decreased eye redness was observed. We found that sensory irritation (often expressed as dryness) measured simultaneously by questionnaires, in general occurred before any increased eye redness. The study indicates that photographic measurement of eye redness is reproducible, sensitive, unbiased and therefore a useful tool in environmental studies. Furthermore we demonstrated that the relation between eye redness and eye irritation is interestingly biphasic and may need further clarification.
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References
Bach B, Mølhave L, Pedersen OF (1988) Human reactions to formaldehyde vapors. Institute of Environmental and Occupational Medicine, Aarhus (In Danish with English summary)
Bisgaard H, Thorsen S (1986) Leukotrienes in allergic and inflammatory conditions. Ugeskr Læg 148:3435–3439
Colligan MJ (1981) The psychological effects of indoor air pollution. Bull NY Acad Med 57:1014–1025
Draize JH, Woddard G, Calvery HO (1944) Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther 82:377–390
Ganong WF (1977) Review of medical physiology. Lung medical publications, Los Angeles
Hammarström S (1983) Leukotrienes. Ann Rev Biochem 52:355–377
Heyden G, Mattsson U (1988) Computer aided photograph analyses in oral medicine — a pilot study. Swed Dent J 12:93–99
Huskisson EC (1983) Visual analoque scales, In: Pain measurement and assessment. Melzack R (ed) Raven Press, New York, pp 33–37
Kirkegaard J, Secher C, Mygind N (1982) Effect of the H1 antihistamine chlorpheniramine maleate on histamine — induced symptoms in the human conjunctiva. Allergy 37:203–208
Kjærgaard S, Pedersen OF (1989) Dust exposure, eye redness, eye cytology and mucous membrane irritation in a tobacco industry. Int Arch Occup Environ Health 61:519–525
Kjærgaard S, Pedersen OF, Mølhave L (1989) Human exposure to indoor pollutants: n-decane. Environ Int 15:473–482
Kovalcheck SW, Chen P, Wadleigh FR, Zweifach BW (1982) Characterization of conjunctival microvessels/network in diabetic and control individuals — a computer based method. Microvasc R 23:262
Melzack R (1983) The McGill pain questionnaire. In: Pain measurements and assessment. Melzack R (ed) Raven Press, New York, pp 41–47
Møller C, Björksten B, Nilsson G, Dreborg S (1984) The precision of the conjunctival provocation test. Allergy 39:37–41
Norusis M (1986) SPSS/PC+ advanced statistics. SPSS Inc, Chicago
Norusis M (1988) SPSS/PC basic statistics. SPSS Inc, Chicaco
Siegel S (1956) Nonparametric statistics for the behavioral sciences. McGraw-Hill, Kogakuska, LTD, Tokyo
Taudorf E, Laursen LC, Lanner Å, Björksten B, Dreborg S, Søborg M, Weeke B (1987) Oral immunotherapy in birch pollen hay fever. J Allergy Clin Immunol 80:153–161
Tsusima N, Satok T, Koyama T, Kikuchi Y, Nitta J (1982) Pharmacological effects on microcirculation (MC) of human conjunctiva. Microvasc R 24:231
Wandall JH (1988) Neutrophilic granulocyte function. Dan Med Bull 35:237–252
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Kjærgaard, S.K., Pedersen, O.F., Taudorf, E. et al. Assessment of changes in eye redness by a photographic method and the relation to sensory eye irritation. Int. Arch Occup Environ Health 62, 133–137 (1990). https://doi.org/10.1007/BF00383590
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DOI: https://doi.org/10.1007/BF00383590