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Effect of aspirin on mitochondrial mutagens in Saccharomyces cerevisiae

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Summary

The mitochondrial mutation petite was induced in yeast cells by ethidium bromide (EB), Adriamycin (ADR) and 4-nitroquinoline-N-oxide (NQO). In the presence of aspirin in concentrations ranging from 0.1 to 1.0 mg/ml, the mutagenicity of EB and ADR was reversed but petite induction by NQO was unaffected. At these concentrations, aspirin also reversed mitochondrial inhibition by oligomycin, a non-mutagenic inhibitor of the organellar ATPase complex.

Cells grown in the presence of aspirin alone showed a significantly higher rate of oxygen uptake than untreated control cultures when the drug concentration ranged from 0.05 to 1.0 mg/ml. At concentrations of 2 mg/ml and above, aspirin inhibited mitochondrial respiration.

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Author notes

  1. Ian J. Bruce

    Present address: Peadiatric Research Unit, Prince Philip Research Laboratories, Guy's Hospital Medical School, London Bridge, London, England

Authors and Affiliations

  1. Department of Botany and Microbiology, University College London, Gower Street, WC1E 6BT, London, England

    Ian J. Bruce & David Wilkie

Authors
  1. Ian J. Bruce
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  2. David Wilkie
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Communicated by F. Kaudewitz

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Bruce, I.J., Wilkie, D. Effect of aspirin on mitochondrial mutagens in Saccharomyces cerevisiae . Molec. Gen. Genet. 194, 299–302 (1984). https://doi.org/10.1007/BF00383531

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  • DOI: https://doi.org/10.1007/BF00383531

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