Summary
The gene clw can be integrated into another site in the X chromosome to form the mutable two gene transposon system sn::Tn-clw. When brought under the common control of the transposon, sn and clw can concomitantly mutate and manifest themselves. Tn-clw was found to move from the sn region to a position of±52 m.u. This transposition was associated with changes in sn::Tn-clw:(1) loss of the instability property by the sn + allele; (2) appearance of a new lethal allele, clw 9, designated as a transposon allele. Based on analysis of the direction and frequency of the sn-clw mutations, the unstable genes of the sn locus were grouped in three pleiades. Interallelic mutations occurred regularly at frequencies of 0.1%–5.6% with changes in the manifestation of the clw mutation specific to each pleiade. Transition from one pleiade to another was rare (5×10−4), and it was associated with a new phenotypic expression of the sn and clw alleles. The mutational differences between the pleiades are presumably related to differences in the localization of Tn-clw within the sn locus.
It was shown that the presence of Tn promotes recombination events in the rightmost portions of the sn-oc interval.
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Communicated by M.M. Green
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Yurchenko, N.N., Zakharov, I.K. & Golubovsky, M.D. Unstable alleles of the singed locus in Drosophila melanogaster with reference to a transposon marked with a visible mutation. Molec. Gen. Genet. 194, 279–285 (1984). https://doi.org/10.1007/BF00383528
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DOI: https://doi.org/10.1007/BF00383528