Summary
The influence of the lead content of drinking water on the transplacental transfer of lead was investigated in 70 pregnant women living in a rural area of Belgium. The mothers were divided into 2 groups: group A: morning water lead below 50 μg/liter; group B: morning water lead above this value. In group A, the mean lead content of water was 11.8 μg/liter and in group B it amounted to 247.4 μg/liter.
The difference in the mean lead concentration between the two groups were for maternal blood: 3.2 μg/100 ml, for umbilical cord blood: 3.3 μg/100 ml, and for placenta: 3.6 μg/100 g. These differences are statistically significant.
There were significant correlations between water lead and lead concentration in blood (mother, newborn) or placenta. An increment of water lead concentration from 50 to 500 μg/liter increases blood lead concentration in mother and in newborn by about 3 μg/100 ml and in placenta by about 2.5 μg/100 g (wet weight).
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References
Addis, G., Moore, M. R.: Lead levels in the water of suburban Glasgow. Nature 252, 120–121 (1974)
Berlin, A., Amavis, R., Langevin, H.: Research on lead in drinking water in Europe (in relation to the possible uptake of lead by man) prepared for the Working Group on Health Hazards from Drinking Water. World Health Organization, London September 26–30,1977
Buchet, J. P., Roels, H., Hubermont, G., Lauwerys, R.: Placental transfer of lead, mercury, cadmium and carbon monoxide in women. II. Influence of some epidemiological factors on the frequency distributions of the biological indices in maternal and umbilical cord blood. Environ. Res. (in press)
Elwood, P. C., St. Leger, A. S., Morton, M.: Dependence of blood — lead on domestic water lead. Lancet, 1, 1295 (1976)
Gershanik, J. J., Brooks, G. G., Little, J. A.: Blood lead values in pregnant women and their offspring. Amer. J. Obst. Gyn. 129, 508–511 (1974)
Kretzchmar, J. G., Delespaul, I., de Rijck T., Verduyn, G.: The Belgian network for the determination of heavy metals. Atmosph. Environ. 11, 263–271, 1977
Lauwerys, R., Buchet, J. P., Roels, H., Hubermont, G.: Placental transfer of lead, mercury, cadmium and carbon monoxide in women. I. Comparison of the frequency distributions of the biological indices in maternal and umbilical cord blood. Environ. Res. (in press)
Mc Laughlin, M., Stopps, G.: Smoking and lead. Arch. Environ. Hlth. 26, 131–136 (1973)
Osborne, R. G., Raye, J. R., Bowers, G. N., Lepow, M. L.: The influence of environmental factors on maternal and neonatal blood lead levels. Conn. Med. 40, 452–455 (1970)
Roels, H., Hubermont, G., Buchet, J. P., Lauwerys, R.: Placental transfer of lead, mercury, cadmium and carbon monoxide in women. III. Factors influencing the accumulation of heavy metals in placenta and relationship between metal concentration in placenta and in maternal and cord blood. Environ. Res. (in press)
Schaller, K. H., Schiele, R., Weltle, D., Krause, C., Valentin, H.: Der Blutbleispielgel von Mutter und Kind und der Bleigehalt der menschlichen Placenta in Abhängigkeit vom Lebensraum. Int. Arch. Occup. Environ. Hlth. 37, 265–276 (1976)
Tola, S., Nordman, C. H.: Smoking and blood-lead concentration in lead-exposed workers and an unexposed population. Environ. Res. 13, 250–255 (1977)
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Hubermont, G., Buchet, J.P., Roels, H. et al. Placental transfer of lead, mercury and cadmium in women living in a rural area. Int. Arch Occup Environ Heath 41, 117–124 (1978). https://doi.org/10.1007/BF00381796
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DOI: https://doi.org/10.1007/BF00381796