Summary
In previous studies investigating long latency components of the event-related potential (ERP), schizophrenic patients generally showed reduced P3 amplitudes and in some studies prolonged N2 or P3 latencies. As there is a higher risk of offspring of schizophrenics than of mentally healthy parents developing this disease, the present study was intended to clarify whether ERP components (in particular the N2 and P3) differ between these two groups of children. Twelve high-risk and 12 age-matched control children (aged 9–16 years) performed an auditory oddball task in order to assess late ERP components. This task required the subject to covertly count rare target tone pips (P = 0.2) irregularly interspersed among frequent standard tone pips (P = 0.8) in two series of 400 pips. ERPs were recorded from midline electrodes (Fz, Cz, Pz). The results indicated distinctly prolonged N2 and P3 latencies in ERPs to target stimuli in children of schizophrenic patients. These findings suggest a slowed target classification in these children.
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Angst J, Scharfetter C (1989) Familial aspects of bipolar schizoaffective disorders. In: Kisker KP, Lauter H, Meyer JE, Müller C, Strömgren E (eds) Psychiatrie der Gegenwart, Bd 5. Affektive Psychosen. Springer, Berlin Heidelberg New York (in press)
APA (1980) Diagnostic and statistical manual of mental disorders (DSM-III), 3rd edn. American Psychiatric Association, Washington, DC
Baribeau-Braun J, Picton TW, Gosselin J (1980) Schizophrenia: a neurophysiological evaluation of abnormal information processing. Science 219:874–876
Brecher M, Porjesz B, Begleiter H (1987) The N2 component of the event-related potential in schizophrenic patients. Electroencephalogr Clin Neurophysiol 66:369–375
Courchesne E (1978) Neurophysiological correlates of cognitive development: changes in long-latency event-related potentials from childhood to adulthood. Electroencephalogr Clin Neurophysiol 45:468–482
Ford J, Pfefferbaum A, Roth WT, White P (1987) Controlled and automatic processing in schizophrenics: an ERP study. Abstract, ICON IV, Paris, June 14–19
Friedman D, Vaughan HG Jr, Erlenmeyer-Kimling L (1982) Cognitive brain potentials in children at risk for schizophrenia: preliminary findings. Schizophr Bull 8:514–531
Friedman D, Braun C III, Cornblatt B, Vaughan HG Jr, Erlenmeyer-Kimling L (1984) Changes in the late taskrelated brain potentials during adolescence. In: Karrer R, Cohen J, Tueting P (eds) Brain and information: eventrelated potentials. Ann NY Acad Sci Vol 425, pp 344–352
Kornhuber HH (1984) Towards a more efficient treatment of schizophrenia I via earlier diagnosis by neurophysiological, chemical or neuropsychological methods. In: Meyer BJ, Kramer S (eds) Neuronal communications. Balkemor, Rotterdam, pp 213–229
Kurtzberg D, Vaughan HG Jr, Courchesne E, Friedman D, Harter MR, Putnam L (1984) Developmental aspects of event-related potentials. In: Karrer R, Cohen J, Tueting P (eds) Brain and information: event-related potentials. Ann NY Acad Sci Vol 425, pp 300–318
Modrzewska K (1980) The offspring of schizophrenic parents in a North Swedish isolate. Clin Genet 17:191–201
Näätänen R, Simpson P, Loveless NE (1982) Stimulus deviance and evoked potentials. Biol Psychol 14:53–98
Pfefferbaum A, Winegrat BG, Ford JM, Roth WT, Kopell BS (1984) Clinical application of the P3 component of event-related potentials. II. Dementia, depression and schizophrenia. Electroencephalogr Clin Neurophysiol 59:104–124
Pritchard WS (1981) Psychophysiology of P300. Psychol Bull 89:506–540
Ritter W, Simson R, Vaughan HG Jr, Friedman D (1979) A brain event related to the making of a sensory discrimination. Science 203:1358–1361
Rosenthal D (1966) The offspring of schizophrenic couples. J Psychiatr Res 4:169
Roth WT, Cannon EH (1972) Some features of the auditory evoked responses in schizophrenics. Arch Gen Psychiatry 27:466–477
Roth WT, Horvath TB, Pfefferbaum A, Tinklenberg JR, Mezzich J, Kopell BS (1979) Late event-related potentials and schizophrenia. In: Begleiter H (eds) Brain potentials and behavior, vol 2. Downstate series of research in psychiatry and psychology. Plenum Press, New York, pp 499–515
Roth WT, Pfefferbaum A, Horvath TB, Berger PA, Kopell BS (1980) P3 reduction in auditory evoked potentials of schizophrenics. Electroencephalogr Clin Neurophysiol 49:497–505
Rutschmann J, Cornblatt B, Erlenmeyer-Kimling L (1977) Sustained attention in children at risk for schizophrenia: report on a continuous performance test. Arch Gen Psychiatry 34:571–575
Saitoh O, Niwa SI, Hiramatsu KI, Kameyama T, Rymar K, Itoh K (1984) Abnormalities in late positive components of event-related potentials may reflect a genetic predisposition to schizophrenia. Biol Psychiatry 19:293–303
Sutton S, Braren M, Zubin J, John ER (1965) Evoked potential correlates of stimulus uncertainty. Science 150:1187–1188
Verleger R, Cohen C (1978) Effects of certainty, modality shift and guess outcome on evoked potentials and reaction time in chronic schizophrenics. Psychol Med 8:81–93
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Schreiber, H., Stolz, G., Rothmeier, J. et al. Prolonged latencies of the N2 and P3 of the auditory event-related potential in children at risk for schizophrenia. Eur Arch Psychiatr Neurol Sci 238, 185–188 (1989). https://doi.org/10.1007/BF00381462
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DOI: https://doi.org/10.1007/BF00381462