Summary
The neurotoxic n-hexane metabolite 2,5-hexanedione was detected by gas chromatography—mass spectrometry in urine samples from human subjects not exposed to n-hexane or related hydrocarbons. Quantitative determinations by multiple ion detection revealed an amount of 2,5-hexanedione ranging from 0.12 to 0.78 mg/l (0.45 ± 0.20 mg/l; \((0.45 \pm 0.20{\text{mg/l; }}\bar x \pm {\text{SD}}).\) The amounts of 2,5-hexanedione actually measured in urinary extracts depended on the pH employed for acid hydrolysis of the samples.
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Fedtke, N., Bolt, H.M. Detection of 2,5-hexanedione in the urine of persons not exposed to n-hexane. Int. Arch Occup Environ Heath 57, 143–148 (1986). https://doi.org/10.1007/BF00381382
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DOI: https://doi.org/10.1007/BF00381382