Summary
In order to evaluate the correlation between peripheral blood leukocyte DNA adducts as an indicator of exposure to polycyclic aromatic hydrocarbons (PAH) and the airborne contamination of PAH at the work places, a survey of a cohort of coke-oven workers has been carried out. In each workplace, total and specific PAH airborne concentrations were measured. Among the job title groups, the highest proportion of subjects with levels of adducts above the detection limit and the highest mean value were observed in the door-operators. The correlation between median values of environmental benzo(a)pyrene concentration and mean values of adducts concentration support the fact that the maintenance workers group has a higher relative risk (RR) to have detectable level of PAH-adducts, which is estimated to be 1.84 for an increase of 1 μg/m3 of benzo(a)pyrene.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Commission of the European Communities (1988) Indicators for assessing exposure and biological effects of genotoxic agents. Consensus report. Eds Aitio et al. EUR 11642 EN
Goldring JM, Lucier GW (1990) Protein and DNA adducts. In: Biological markers in epidemiology (Hulka BS, Wilcosky TC, Griffith JD eds) Oxford University Press, New York, pp 78–104
Hams CC (1989) Interindividual variation among humans in carcinogen metabolism, DNA adducts formation and DNA repair. Carcinogenesis, 10: 1563–1566
International Agency for Research on Cancer (1987) IARC Monographs on the evaluation of carcinogenic risk to humans. Suppl 7, IARC, Lyon
Newman M, Weston A, Carver DC, Mann DL, Hams CC (1990) Serological characterization of polycyclic aromatic hydrocarbon diolepoxide-DNA adducts using monoclonal antibodies. Carcinogenesis 11:1903–1907
Perera F, Jeffrey A, Santella RM, Brenner D, Mayer J, Latriano L, Smith S, Young TL, Tsai WY, Hemminki K, Brand-Rauf P (1990) Complex mixtures and cancer risk. Ed Vaino H, Sorsa M & McMichael AJ, Lyon, IARC
Samshudin AKM, Sinopoli NT, Hemminki K, Boesch RR, Harris CC (1985) Detection of bezo(a)-pyrene: DNA adduction in human white blood cell. Cancer Research 45:66–68
Soini E, Lövgren T (1987) Time-resolved fluorescence of lanthanide probes and applications in biotechnology. Crit Rev Anal Chem 18:105–153
Weston A, Willey JC, Manchester DK, Wilson VL, Brooks BR, Choi JS, Poirier MC, Trivets GE, Newman MJ, Maim DL, Harris CC (1988) Dosimeters of human exposure to carcinogens: Polycliclic aromatic hydrocarbon-macromolecular adducts. Methods for detecting DNA damaging agents in humans: applications in cancer epidemiology and prevention. IARC Scientific Publication 89:181–189
Weston A, Manchester DK, Poirier MC, Choi JS, Trivets GE, Mann DL, Harris CC (1989) Derivative fluorescence in spectral analysis of polycyclic aromatic hydrocarbon DNA adducts human placenta. Chem Res Toxicol 2:104–108
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Assennato, G., Ferris, G.M., Foà, V. et al. Correlation between PAH airborne concentration and PAH-DNA adducts levels in coke-oven workers. Int. Arch Occup Environ Heath 65 (Suppl 1), S143–S145 (1993). https://doi.org/10.1007/BF00381327
Issue Date:
DOI: https://doi.org/10.1007/BF00381327