Summary
The frequency of an abnormal response to the Dexamethasone Suppression Test (DST) was examined in 24 non-depressed patients in the early stages of Alzheimer dementia. Results were compared with those obtained in 51 geriatric medical inpatients: 15 with major depression, 18 with dysthymic disorder and 18 normal controls. As an abnormal lack of suppression was found in 9 demented patients, in 9 with major depression, 1 with dysthymic disorder and in 2 the normal controls, it appears that DST alone is not useful in distinguishing dementia, even in its early stages, from major depression. In our experience abnormal DST results in demented patients were unrelated to mood.
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References
American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders, 3rd edn. APA, Washington, DC
Asnis GM, Sachar EJ, Halbreich U, Nathan RS, Ostrow L, Halpern FS (1981) Cortisol secretion and dexamethasone response in depression. Am J Psychiatry 138:1218–1221
Balldin J, Gottfries CG, Karlsson I, Lindstedt G, Langstöm G, Walinder J (1983) Dexamethasone suppression test and serum prolactin in dementia disorders. Br J Psychiatry 143:277–281
Brown WA (1981) The dexamethasone suppression test: clinical applications. Psychosomatics 22:951–954
Carroll BJ, Feinberg M, Greden JF, Tarika J, Albala AA, Haskett RF, James NM, Kronfol Z, Lohr N, Steiner M, Vigne JP de, Young E (1981) A specific laboratory test for the diagnosis of melancholia. Standardization, validation and clinical utility. Arch Gen Psychiatry 38:15–22
Dam H, Mellerup ET, Rafaelsen OJ (1985) The dexamethasone suppression test in depression. J Affective Disord 8:95–103
Galletly CA, Morris H, Newcombe A (1985) The dexamethasone suppression test in elderly, non-depressed patients with dementia. Aust NZ J Psychiatry 19:95–96
Jenike MA, Albert MS (1984) The dexamethasone suppression test in patients with presenile and senile dementia of the Alzheimer's type. J Am Geriatr Soc 32:441–444
Magni G, Schifano F, De Leo D, De Dominicis MG, Garbin A, Zangaglia O (1986) The dexamethasone suppression test in depressed and non depressed geriatric medical inpatients. Acta Psychiatr Scand 73:511–514
Magni G, Schifano F, De Leo D, Zangaglia O (1987) The dexamethasone suppression test in dementia. Ital J Neurol Sci 8:125–128
Pomara N, Oxenkrug GF, McIntyre IM, Block R, Stanley M, Gershon S (1984) Does severity of dementia modulate response to dexamethasone in individuals with primary degenerative dementia. Biol Psychiatry 19:1481–1485
Raskind M, Peskind F, Rivard MF, Veith R, Barnes R (1982) Dexamethasone suppression test and cortisol circadian rhythm in primary degenerative dementia. Am J Psychiatry 139:1468–1471
Rudorfer MY, Clayton PJ (1981) Depression, dementia and dexamethasone suppression. Am J Psychiatry 138:701
Spar JE, Gerner R (1982) Does the dexamethasone suppression test distinguish dementia from depression? Am J Psychiatry 139:238–240
Tourigny-Rivard MF, Raskind M, Rivard D (1981) The dexamethasone suppression test in an elderly population. Biol Psychiatry 16:1177–1184
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De Leo, D., Schifano, F. & Magni, G. Results of dexamethasone suppression test in early alzheimer dementia. Eur Arch Psychiatr Neurol Sci 238, 19–21 (1988). https://doi.org/10.1007/BF00381074
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DOI: https://doi.org/10.1007/BF00381074