Long-term mercury excretion in urine after removal of amalgam fillings

  • J. Begerow
  • D. Zander
  • I. Freier
  • L. Dunemann
Original Article


The long-term urinary mercury excretion was determined in 17 28- to 55-year-old persons before and at varying times (up to 14 months) after removal of all (4–24) dental amalgam fillings. Before removal the urinary mercury excretion correlated with the number of amalgam fillings. In the immediate post-removal phase (up to 6 days after removal) a mean increase of 30% was observed. Within 12 months the geometric mean of the mercury excretion was reduced by a factor of 5 from 1.44 μg/g (range: 0.57–4.38 μg/g) to 0.36 μg/g (range: 0.13–0.88 μg/g). After cessation of exposure to dental amalgam the mean half-life was 95 days. These results show that the release of mercury from dental amalgam contributes predominantly to the mercury exposure of non-occupationally exposed persons. The exposure from amalgam fillings thus exceeds the exposure from food, air and beverages. Within 12 months after removal of all amalgam fillings the participants showed substantially lower urinary mercury levels which were comparable to those found in subjects who have never had dental amalgam fillings. A relationship between the urinary mercury excretion and adverse effects was not found. Differences in the frequency of effects between the pre- and the post-removal phase were not observed.

Key words

Biological monitoring Mercury exretion Urine Dental amalgam Removal 


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  1. 1.
    Abraham JE, Svare CW, Frank CW (1984) The effect of dental amalgam restorations on blood mercury levels. J Dent Res 63:71–73Google Scholar
  2. 2.
    Aronsson AM, Lind B, Nylander M, Nordberg M (1989) Dental amalgam and mercury. Biol Metals 2:25–30Google Scholar
  3. 3.
    Beratungskommission Toxikologie der Deutschen Gesellschaft für Pharmakologie und Toxikologie (1990) Zur Toxikologie von Zahnfüllungen aus Amalgam. Med Klin 85:350–352Google Scholar
  4. 4.
    Berlin M (1986) Mercury. In: Friberg L, Nordberg GF, Vouk VB (Eds) Handbook on the toxicology of metals. Elsevier, Amsterdam New York OxfordGoogle Scholar
  5. 5.
    Brune D, Evje DM (1985) Man's mercury loading from dental amalgam. Sci Total Environ 44:51–63Google Scholar
  6. 6.
    Ellingsen DG, Thomassen Y, Langard S, Kjuus H (1993) Urinary mercury excretion in chloralkali workers after the cessation of exposure. Scand J Work Environ Health 19:334–341Google Scholar
  7. 7.
    Geurtsen W (1990) Amalgam in der Diskussion — Zur Frage der Amalgamtoxizität. Phillip J 3:121–128Google Scholar
  8. 8.
    Langworth S, Elinder C-G, Akesson A (1988) Mercury exposure from dental fillings. I. Mercury concentrations in blood and urine. Swed Dent J 12:69–70Google Scholar
  9. 9.
    Langworth S, Elinder C-G, Göthe C-J, Vesterberg O (1991) Biological monitoring of environmental and occupational exposure to mercury. Int Arch Occup Environ Health 63:161–167Google Scholar
  10. 10.
    Molin M (1990) Mercury release from dental amalgam in man. Swed Dent J, Suppl 71:1–73Google Scholar
  11. 11.
    Molin M, Marklund S, Bergman B, Bergman M, Stegman E (1987) Plasma-selenium, glutathione peroxidase in erythrocytes and mercury in plasma in patients alleged subject to oral galvanism. Scand J Dent Res 95:328–334Google Scholar
  12. 12.
    Olstad ML, Hooland RI, Wandel N, Hengsten Pettersen A (1987) Correlation between amalgam restorations and mercury concentrations in urine. J Dent Res 66:1179–1182Google Scholar
  13. 13.
    Roels HA, Boeckx M, Ceulemans E, Lauwerys RR (1991) Urinary excretion of mercury after occupational exposure to mercury vapour and influence of the chelating agent meso-2,3dimercaptosuccinic acid (DMSA). Br J Ind Med 48:247–253Google Scholar
  14. 14.
    Snapp KR, Boyer DB, Peterson LC, Svare CW (1989) The contribution of dental amalgam to mercury in blood. J Dent Res 68:780–785Google Scholar
  15. 15.
    Taskinen H, Kinnune E, Riihimäki V (1989) A possible case of mercury-related toxicity resulting from grinding of old amalgam fillings. Scand J Work Environ Health 15:302–304Google Scholar
  16. 16.
    Vimy MJ, Lorscheider TL (1984) Intra-oral air mercury released from dental amalgam. J Dent Res 64:1069–1071Google Scholar
  17. 17.
    Weiner JA, Nylander M, Berglund F (1990) Does mercury from amalgam restorations constitute a health hazard? Sci Total Environ 99:1–22Google Scholar
  18. 18.
    Zander D, Ewers U, Freier I, Westerweller S, Jermann E, Brockhaus A (1990) Untersuchungen zu Quecksilberbelastung der Bevölkerung II. Quecksilberfreisetzung aus Amalgamfül-lungen Zbl Hyg 190:325–334Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • J. Begerow
    • 1
  • D. Zander
    • 1
  • I. Freier
    • 1
  • L. Dunemann
    • 1
  1. 1.Medizinisches Institut für UmwelthygieneDüsseldorfGermany

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