Summary
Experiments in vitro have been conducted to determine the effect of mineral dusts (quartz, bentonite, illite, kaolin, and coal) on rat peritoneal macrophages. The authors found a connection between the cytotoxic effect, measured by the in vitro TTC reduction of certain aluminium silicates (kaolin, illite, bentonite), and the degree of methylene blue and paraquat adsorption capacity. In the case of bentonite, the cytotoxic effect of the dust decreases with an inverse ratio with the increasing amount of paraquat adsorption. In the case of maximal paraquat adsorption the TTC-RA50 value changed such an extent in comparison with bentonite adsorbed no paraquat that characteristics of dusts with no harmful effect. It is assumed that in the in vitro cytotoxic effect of bentonite, those groups play a role, which participate in cation exchange.
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Adamis, Z., Timár, M. Effects of various mineral dusts on macrophages in vitro. Int. Arch Occup Environ Heath 37, 301–307 (1976). https://doi.org/10.1007/BF00380113
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DOI: https://doi.org/10.1007/BF00380113