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Serum vitamin D metabolites in cadmium-exposed persons with renal damage

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Summary

Serum concentrations of 25-hydroxyvitamin D [25(OH)D], 24,25-dihydroxyvitamin D [24,25(OH)2D], and 1α,25-dihydroxyvitamin D [1α,25(OH)2D] were measured in ten cadmium (Cd)-exposed subjects and five non exposed subjects. The Cd-exposed subjects were divided into two groups according to serum 1α,25(OH)2D levels. No significant differences for 25(OH)D were found between the Cd-exposed group with low or normal serum 1α,25(OH)2D and the non exposed group. The concentrations of 24,25(OH)2D were the lowest in the Cd-exposed group with low serum 1α,25(OH)2D, highest in the non exposed group, and significantly lower in the Cd-exposed group with normal serum 1α,25(OH)2D than in the non exposed group. Renal function was much worse in the Cd-exposed group with low serum 1α,25(OH)2D than in the group with normal serum 1α,25(OH)2D. These findings indicate that Cd initially disturbs hydroxylation from 25(OH)D to 24,25(OH)2D and then disturbs hydroxylation from 25(OH)D to 1α,25(OH)2D. The decrease of serum 24,25(OH)2D and 1α,25(OH)2D in Cd-exposed subjects is not due to a decrease of the serum 25(OH)D level.

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References

  1. Bernard A, Buchet JP, Roels H, Masson P, Lauwerys R (1978) Renal excretion of proteins and enzymes in workers exposed to cadmium. Eur J Clin Invest 9:11–22

    Google Scholar 

  2. Binderman I, Sömjen D (1984) 24,25-dihydroxycholecalciferol induces the growth of chick cartilage in vitro. Endocrinol 115:430–432

    Google Scholar 

  3. Clemens TL, Hendy GN, Papapoulos SE, Fraher LJ, Care AD, O'riordan JLH (1979) Measurement of 1,25-dihydroxy cholecalciferol in man by radioimmunoassay. Clin Endocrinol 11:225–234

    Google Scholar 

  4. Corvol MT, Dumontier MF, Garabedian M, Rappaport R (1978) Vitamin D and cartilage. II. Biological activity of 25-hydroxycholecalciferol and 24,25- and 1,25-dihydroxycholecalciferols on cultured growth plate chondrocytes. Endocrinol 102:1269–1274

    Google Scholar 

  5. Friberg L, Elinder CG, Kjellström T, Nordberg GF (1986) Cadmium and health: A toxicological and epidemiological appraisal. Vol II Effects and response. CRC Press, Boca Raton, Florida

    Google Scholar 

  6. Haussler MR, Baylink DJ, Hughes MR, Brumbach PF, Wergedal JB, Slen FH, Nielsen RL, Counts SJ, Bursac ND, McCain TA (1976) The assay of 1,25-dihydroxyvitamin D3: physiologic modulation of circulating hormone levels. Clin Endocrinol 5:151–165

    Google Scholar 

  7. Henry HL, Norman AW (1978) Vitamin D: Two dihydroxylated metabolites are required for normal chicken egg hatchability. Science 201:835–837

    Google Scholar 

  8. Hinek A, Reiner A, Poole AR (1987) The calcification of cartilage matrix in chondrocyte culture: studies of the C-propeptide of type II collagen (chondrocalcin). J Cell Biol 104:1435–1441

    Google Scholar 

  9. Holic MF, Baxter LA, Schraufrogel PK, Tavela TE, Deluca HF (1976) Metabolism and biological activity of 24,25-dihydroxyvitamin D3 in the chick. J Biol Chem 251:397–402

    Google Scholar 

  10. Juttmann JR, Buurman CJ, Kam ED, Visser TJ, Birkenhager JC (1981) Serum concentrations of metabolites of vitamin D in patients with chronic renal failure (CRF). Consequences for the treatment with 1-α-hydroxyderivatives. Clin Endocrinol 14:225–236

    Google Scholar 

  11. Juttmann JR, Visser TJ, Buurman C, Kam E, Birkenhäger JC (1981) Seasonal fluctuations in serum concentrations of vitamin D metabolites in normal subjects. Br Med J 282:1349–1352

    Google Scholar 

  12. Kajikawa K, Kitagawa M, Nakanishi I, Ueshima H, Katsuda S, Kuroda K (1974) A pathological study of itai-itai disease. J Juzen Med Soc 83:309–347 (in Japanese)

    Google Scholar 

  13. Kano K, Hosaki J, Yata J, Yoshida H, Abe E, Suda T (1979) Competitive protein binding assay for 25-hydroxyvitamin D and 24R,25-dihydroxyvitamin D in human serum. Vitamins (Japan) 53:11–19 (in Japanese)

    Google Scholar 

  14. Kitagawa M (1982) Autopsy cases of patients with itai-itai disease in Toyama Prefecture. Kankyo Hoken Report No 48: 204–206 (in Japanese)

  15. Lidor C, Atkin I, Ornoy A, Dekel S, Edelstein S (1987) Healing of rachitic lesions in chicks by 24R,25-dihydroxycholecalciferol administered locally into bone. J Bone Mineral Res 2:91–98

    Google Scholar 

  16. Lauwerys RR, Roels HA, Buchet JP, Bernard A, Stanescu D (1979) Investigations on the lung and kidney function in workers exposed to cadmium. Environ Health Perspect 28:137–145

    Google Scholar 

  17. Nakagawa S (1960) A study of osteomalacia in Toyama Prefecture (so-called itai-itai disease). J Radiol Phys Ther Univ Kanazawa 56:1–51 (in Japanese)

    Google Scholar 

  18. Nishii Y, Nanjo M (1981) Methods for assay of vitamin D 3. Multiple assay of vitamin D and it's metabolites. Vitamins (Japan) 55:595–605 (in Japanese)

    Google Scholar 

  19. Nogawa K, Kobayashi E, Honda R, Ishizaki A, Kawano S, Ohmura T, Nakagawa H, Toga H, Matsuda H (1981) Clinico-chemical studies on chronic cadmium poisoning (Part 5) Renal functions. Jpn J Hyg 36:512–517 (in Japanese)

    Google Scholar 

  20. Nogawa K, Kobayashi E, Yamada Y, Honda R, Kido T, Tsuritani I, Ishizaki M (1984) Parathyroid hormone concentration in the serum of people with cadmium induced renal damage. Int Arch Occup Environ Health 54:187–193

    Google Scholar 

  21. Nogawa K, Tsuritani I, Kido T, Honda R, Yamada Y, Ishizaki M (1987) Mechanism for bone disease found in inhabitants environmentally exposed to cadmium: decreased serum 1α,25-dihydroxyvitamin D level. Int Arch Occup Environ Health 59:21–30

    Google Scholar 

  22. Norman AW, Leathers V, Bishop JE (1983) Normal egg hatchability requires the simultaneous administration to the hen 1α,25-dihydroxycholecalciferol and 24R,25-dihydroxycholecalciferol. J Nutr 113:2505–2515

    Google Scholar 

  23. Ornoy A, Goodwin D, Noff D, Edelstein S (1978) 24,25-dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation. Nature 276:517–519

    Google Scholar 

  24. Parviainen MT, Savolainen KE, Korhonen PH, Alhava EM, Visakorpi JK (1981) An improved method for routine determination of vitamin D and its hydroxylated metabolites in serum from children and adults. Clin Chim Acta 114:233–247

    Google Scholar 

  25. Piscator M (1978) β2-Microglobulin in the diagnosis of chronic cadmium poisoning. In: Peterson PA, Lauwerys R (eds) Beta2-microglobulin in proliferative disorders and heavy metal intoxication. Eur Press Gent, pp 69–77

    Google Scholar 

  26. Shepard RM, Horn RL, Hamstra J, Deluca HF (1979) Determination of vitamin D and its metabolites in plasma from normal and anephric man. Biochem J 182:55–69

    Google Scholar 

  27. Schwartz Z, Boyan B (1988) The effects of vitamin D metabolites on phospholipase A2 activity of growth zone and resting zone cartilage cells in vitro. Endocrinol 122:2191–2198

    Google Scholar 

  28. Sömjen D, Binderman I, Weisman Y (1983) The effect of 24R,25-dihydroxycholecalciferol on ornithine decarboxylase activity and on DNA synthesis in the epiphysis and diaphysis of rat bone and in the duodenum. Biochem J 214:293–298

    Google Scholar 

  29. Suda T, Ogata E, Ogura Y, Nishi Y (1982) Vitamin D. Tokyo, Kodansha (in Japanese)

    Google Scholar 

  30. Taylor CM, Mawer EB, Wallace JE, John JT, Cochran M, Russell RGG, Kanis JA (1978) The absence of 24,25-dihydroxycholecalciferol in anephric patients. Clin Sci Mol Med 55:541–547

    Google Scholar 

  31. Taylor CM, John J, John JH, Wallace JE, Mawer EB (1979) 1,25-dihydroxycholecalciferol in human serum and its relationship with other metabolites of vitamin D3. Clin Chim Acta 96:1–8

    Google Scholar 

  32. Yamamoto I, Asonuma K, Yamamura S, Dokoh S, Kitamura N, Aoki J, Hino M, Shigeno C, Morita R, Torizuka K (1986) Evaluation of serum 1,25-dihydroxyvitamin D measurement in healthy normals. Vitamins (Japan) 60:371–377 (in Japanese)

    Google Scholar 

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Authors and Affiliations

  1. Department of Hygiene, School of Medicine, Chiba University, 280, Inohana, Chiba, Japan

    Koji Nogawa

  2. Department of Hygiene, Kanazawa Medical University, 920-02, Uchinada, Ishikawa, Japan

    Ikiko Tsuritani, Teruhiko Kido, Ryumon Honda, Masao Ishizaki & Yuichi Yamada

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  1. Koji Nogawa
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  2. Ikiko Tsuritani
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  3. Teruhiko Kido
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  4. Ryumon Honda
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  5. Masao Ishizaki
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  6. Yuichi Yamada
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Nogawa, K., Tsuritani, I., Kido, T. et al. Serum vitamin D metabolites in cadmium-exposed persons with renal damage. Int. Arch Occup Environ Heath 62, 189–193 (1990). https://doi.org/10.1007/BF00379430

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  • DOI: https://doi.org/10.1007/BF00379430

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