Summary
Biological monitoring for carbon disulphide (CS2) exposure performed using the iodine-azide test (IAT) and 2-thiothiazolidine-4-carboxylic acid (TTCA) test in urinalysis of workers with high exposure to CS2 (112–142 mg/m3, n = 34), workers with low exposure (4–7 mg/m3, n = 16), and non-exposed university workers (n =10). Pre-shift and post-shift urine specimens were collected on three consecutive days in the exposed and for only one day in the non-exposed. According to the findings the specificity and the sensitivity seem to be low for the IAT and high for the TTCA test. Contrary to a previous report all pre-shift urine samples showed negative IATs. The TTCA test was positive in pre-shift urine even after 32 to 63.5 h without exposure, and values tended to increase during consecutive days of exposure in highly exposed workers.The possible health implications of these findings should be further investigated.
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van Pouckel, L., van Peteghem, C. & Vanhoorne, M. Accumulation of carbon disulphide metabolites. Int. Arch Occup Environ Heath 62, 479–482 (1990). https://doi.org/10.1007/BF00379067
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DOI: https://doi.org/10.1007/BF00379067